ArticleCureus2025
Ibrutinib-Induced Perianal Rash Complicated by Bacterial Infection in a Patient With Chronic Lymphocytic Leukemia: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, is widely used in the treatment of chronic lymphocytic leukemia (CLL). However, its use is associated with a range of adverse effects, including cutaneous manifestations. We present a case of a 74-year-old male with CLL who developed a perianal rash following four years of ibrutinib therapy. The rash progressively worsened due to a superimposed bacterial infection, resulting in perianal cellulitis with bleeding, severe pain, and difficulty passing stools. The patient was started on antibiotics, and ibrutinib was discontinued. This case highlights an unusual presentation of ibrutinib-induced skin toxicity in the perianal region, complicated by bacterial infection, and underscores the importance of early recognition and management. To the best of our knowledge, this is the first report of such a manifestation, contributing new insights into the spectrum of ibrutinib-associated cutaneous adverse effects.
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