Evidence map›Paper›PMID 40416148›Full record

ArticleCureus2025

Targeting the Odontogenic Keratocysts: Therapeutic Potential of 5-Fluorouracil Through Thymidylate Synthase Inhibition.

G V Reddy, G Siva Prasada Reddy, Vishnu Priyatham, John Jims Veeravalli, Srimounica Kocherlakota

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

G V ReddyDepartment of Oral and Maxillofacial Surgery, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.
G Siva Prasada ReddyDepartment of Oral and Maxillofacial Surgery, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.
Vishnu PriyathamDepartment of Oral and Maxillofacial Surgery, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.
John Jims VeeravalliDepartment of Oral and Maxillofacial Surgery, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.
Srimounica KocherlakotaDepartment of Oral and Maxillofacial Surgery, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Odontogenic keratocysts (OKCs) are aggressive cystic lesions of the jaw with a high recurrence rate. They are benign lesions that arise from dental lamina remnants or basal cells of the overlying epithelium. Various surgical and adjunctive treatments have been explored to minimize recurrence. In this report, we review the literature elucidating the efficacy of 5-fluorouracil (5-FU) topical application for recurrent OKCs and discuss the management of an OKC with 5-FU after enucleation and a 12-month follow-up.

Indexed as

5-fluorouracilodontogenic keratocystrecurrencetargeted therapythymidylate synthase inhibition

Identifiers

PMID40416148
PMCPMC12103102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.