ReviewCureus2025
Therapeutic Drug-Drug Interactions (DDIs) Causing QT Prolongation in Patients With Cancer: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Risk prediction model for severe potential drug-drug interactions in colorectal cancer patients: a real-world data study.Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic drug-drug interactions (DDIs) have the potential to harm the patient by causing serious and unwanted side effects. Patients suffering from cancer are exposed to numerous drugs, such as therapeutic drugs and adjuvant treatments for the comorbidities and the side effects of chemotherapy. The concomitant use of anticancer and adjuvant drugs makes such patients prone to QT prolongation, which could precipitate torsades de pointes or TdP. The current review aims to summarize the prevalence of therapeutic DDIs causing QT prolongation in these patients. A thorough literature search was performed using databases such as PubMed, Google Scholar, and Research Gate. Medical Subject Headings (MeSH) and alternate search terminologies such as "QT prolongation", "Drug interactions", and "Cancer" were used to identify all the relevant articles published in English to date. The data from all such published articles available on the day of the collection were considered and fed into the meta package of R software for measuring the outcomes. The literature search yielded seven unique and relevant articles, which were included in our study. In these studies, therapeutic DDIs causing QT prolongation were found to occur in 3558 out of 8013 patients undergoing evaluation. Their prevalence in patients with cancer was estimated to be 22% with a 95% CI between 4% and 63%. The patient characteristics, such as age, comorbid diseases, drugs for supportive care, and polypharmacy, were identified as risk factors associated with potential DDIs. Our data concluded that 22% of the patients administered anticancer drugs were exposed to concomitant drugs leading to DDIs, which prolonged the QT interval. Thus, the implementation of vigilant measures and precautionary safety interventions becomes vital to forestall QT prolongation and any other adverse cardiac events in this group of patients.
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Registered trials
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