Evidence map›Paper›PMID 40416011›Full record

ArticleJMA journal2025

Significant Increase in Excess Deaths after Repeated COVID-19 Vaccination in Japan.

Hideki Kakeya, Takeshi Nitta, Yukari Kamijima, Takayuki Miyazawa

Abstract read
In one paragraph

Article in JMA journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Reassessing Early COVID-19 Strategies in East Asia: Insights From Japan and Korea.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026
    Review
  3. Article
  4. Review
  5. Observational
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hideki KakeyaInstitute of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan.
Takeshi NittaResearch Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Yukari KamijimaFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan.
Takayuki MiyazawaKyoto Animal Human Organism Research Institute, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although Japan recorded the world's highest rate of COVID-19 messenger ribonucleic acid (mRNA) vaccination doses per capita, COVID-19 cases and deaths exploded after the emergence of the Omicron variant, followed by a significant increase in excess deaths in 2022 and 2023. Although several hypotheses have been proposed to explain these phenomena, the truth remains to be established because sufficient studies and data disclosures have not been conducted to adequately investigate the possible contribution of mRNA vaccines. The causes of the excess deaths from not only COVID-19 but also other factors after repeated mRNA vaccinations must be elucidated, given this could provide valuable information to help combat future infectious disease outbreaks.

Indexed as

adverse reactionschronic infectionexcess deathimmunosuppressionmRNA vaccineSARS-CoV-2

Identifiers

PMID40416011
PMCPMC12095670

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.