ArticleFrontiers in microbiology2025
Combined inactivation of the SOS response with TCA fumarases and the adaptive response enhances antibiotic susceptibility against
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Targeting bacterial DNA damage responses such as the SOS response represents a promising strategy for enhancing the efficacy of existing antimicrobials. This study focuses on a recently discovered DNA damage response mechanism involving tricarboxylic acid cycle (TCA) fumarases and the adaptive response, crucial for Methods: An isogenic collection of Results and discussion: Overall, no significant differences or only moderate increases in susceptibility were observed in the single mutants, with Δ
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