ArticleACS omega2025
Silencing of LncRNA XIST Suppressed Tumor Growth and Metastasis in Papillary Thyroid Carcinoma by Modulating miR-204/FN1 Axis.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Papillary thyroid carcinoma (PTC) is a prevalent endocrine malignancy with a high incidence rate of regional lymph node metastasis. Dysregulation of lncRNA XIST has been observed in various malignancies. This study aims to elucidate the molecular mechanism of lncRNA XIST in PTC metastasis. Quantitative real-time PCR assays were conducted to detect the expression levels of XIST, FN1, and miR-204-5p in PTC tissues. Meanwhile, loss-of-function assays were employed to evaluate the oncogenic roles of XIST in PTC cell lines. Our results revealed significant overexpression of XIST and FN1 in PTC tissues and cell lines, accompanied by decreased levels of miR-204-5p (
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Registered trials
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