ArticleACS omega2025
Detecting Electrical Conductance of PilV in Bulk Solution Using MCBJ.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minor pilins are the first type IV pili (T4P) proteins known to interact with electroactive surfaces, acting as an anode in electron transfer. In this study, we used the mechanically controlled break-junction (MCBJ) technique to measure the electrical conductance in bulk solution of the minor pilin PilV from the acidophile Acidithiobacillus thiooxidans and a lysozyme. Conductance was assessed at two different concentrations and at room temperature, with molecules lacking binding-specific ligands. The signal appeared after the final step of the contact-breakage process of the electrodes. We propose that this signal corresponds to multiple PilV or lysozyme molecules forming a transient junction between the metal contacts, lasting for microseconds. Our findings provide in situ evidence that PilV may contribute to T4P and biofilm conductivity in A. thiooxidans. Additionally, we demonstrate that the MCBJ technique enables real-time conductance detection of molecules in bulk solution.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.