Evidence map›Paper›PMID 40415756›Full record

ArticleInternational journal of clinical pediatric dentistry2025

Estimation of Salivary Nitric Oxide Levels Following Composite Restorations in Primary Molars: An

Krishna Priya, Manju R Nair, K N Suchetha, Prajna Bhandary, K P Sharmila, Prajna P Nayak, Swagata Saha

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In one paragraph

Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Krishna PriyaDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0009-0003-8939-2329
Manju R NairDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-9391-6223
K N SuchethaDepartment of Biochemistry, K S Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-4113-5572
Prajna BhandaryDepartment of Central Research Laboratory, K S Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-3268-6743
K P SharmilaDepartment of Central Research Laboratory, K S Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-1604-2120
Prajna P NayakDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0001-8872-860X
Swagata SahaDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-2343-5977

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims and background: Salivary nitric oxide (NO) has been identified as a promising biomarker for oral inflammation in the pediatric population. However, the effect of different dental materials on NO levels has not been thoroughly investigated. Therefore, our study aims to explore the changes in salivary NO levels following the placement of composite restorations. Materials and methods: A total of 36 children (16 female and 20 male) participated in the study. One tooth of each individual was restored with Tetric Results: The baseline salivary NO level was 104.83 µM/dL, which increased to 180.65 µM/dL after 1 week and 306.82 µM/dL after 1 month. Statistical analysis showed a significant increase in NO levels over time, with all comparisons being statistically significant ( Conclusion: Composite restorations in primary molars lead to a significant increase in salivary NO levels. Clinical significance: Residual monomers can increase the levels of salivary NO, which acts as an antioxidant in the oral cavity. How to cite this article: Priya K, Nair MR, KN S,

Indexed as

Composite resinsDental cariesNitric oxidePrimary teethSaliva

Identifiers

PMID40415756
PMCPMC12096883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.