Evidence map›Paper›PMID 40415723›Full record

ArticleBasic & clinical pharmacology & toxicology2025

Healthcare Providers' Perspectives on Antidepressant Discontinuation: A Focus Group Study.

S Bouarfa, Wilma Göttgens, Suzanne A Ligthart, Otto R Maarsingh, Christiaan H Vinkers, Henricus G Ruhé, Pierre M Bet, Jacqueline G Hugtenburg

Abstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S BouarfaDepartment of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centre, Amsterdam, the Netherlands.ORCID https://orcid.org/0009-0009-8095-5213
Wilma GöttgensDepartment of Primary and Community Care, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.
Suzanne A LigthartDepartment of Primary and Community Care, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.
Otto R MaarsinghAmsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Christiaan H VinkersDepartment of Psychiatry and Department of Anatomy and Neurosciences, Amsterdam University Medical Centre, Amsterdam, the Netherlands.
Henricus G RuhéDepartment of Psychiatry, Radboud University Medical Centre, Nijmegen, the Netherlands.
Pierre M BetDepartment of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centre, Amsterdam, the Netherlands.
Jacqueline G HugtenburgDepartment of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centre, Amsterdam, the Netherlands.

Funding

Stichting Management Apothekers en de Gezondheidszorg (STIMAGSTiMAG
6 · The paper itself

Abstract

Antidepressant (AD) discontinuation in long-term users can be challenging for both patients and healthcare providers (HCPs). Better understanding of how HCPs handle this challenge is needed to improve discontinuation care. Therefore, we identified AD discontinuation barriers and facilitators from the viewpoint of community pharmacists (CPs), general practitioners (GPs), psychiatrists and nurse practitioners and explored their views on their specific roles in AD discontinuation. Two focus group discussions involving four GPs, six pharmacists and three psychiatrists and one interview with a nurse practitioner were performed. Discussions were recorded and transcribed verbatim. Directed content analysis was performed using the theoretical domains framework. Six themes were identified: identification of patients, behaviour of HCPs regarding AD discontinuation, fears and emotions, context and resources, knowledge, evidence and skills and professional attitude. All HCPs stressed the importance of raising awareness for AD discontinuation. Barriers included fear of recurrence or discontinuation symptoms, poor collaboration between HCPs and lack of resources. Facilitators included the availability of tools and guidelines. HCPs were unaware and uncertain about each other's roles and responsibilities and showed motivation to provide guidance. This requires professional collaboration agreements and sufficient resources. Experienced CPs may contribute by identifying AD users and providing information/support.

Indexed as

Antidepressive AgentsAttitude of Health PersonnelHealth PersonnelAdultFemaleFocus GroupsGeneral PractitionersHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedNurse PractitionersPharmacistsProfessional RoleAntidepressive Agentsantidepressantdepressiondiscontinuationgeneral practicehealthcare providersqualitative research

Identifiers

PMID40415723
PMCPMC12104964

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.