Evidence map›Paper›PMID 40415719›Full record

ArticlePediatrics international : official journal of the Japan Pediatric Society

Respiratory syncytial virus infection, non-respiratory syncytial virus respiratory infections, and later wheezing.

Ippei Takahashi, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Yoshikazu Nakayama, Atsushi Momose and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics international : official journal of the Japan Pediatric Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ippei TakahashiDivision of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.ORCID https://orcid.org/0000-0003-4858-2209
Genki ShinodaDivision of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Fumihiko UenoDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Fumiko MatsuzakiDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Aoi NodaDivision of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Keiko MurakamiDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Mami IshikuroDivision of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Taku ObaraDivision of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Yoshikazu NakayamaR&D Clinical Science Div, Janssen Pharmaceutical K.K., Tokyo, Japan.
Atsushi MomoseR&D Clinical Science Div, Janssen Pharmaceutical K.K., Tokyo, Japan.
Naho TsuchiyaDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Satoshi NagaieDepartment of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Soichi OgishimaDepartment of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Gen TamiyaDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Nobuo FuseDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Atsushi HozawaDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Junichi SugawaraSuzuki Memorial Hospital, Iwanuma, Japan.
Shigeo KureMiyagi Children's Hospital, Sendai, Japan.
Shinichi KuriyamaDivision of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Funding

The Japan Agency for Medical Research and Development (AMED) JP17km0105001The Japan Agency for Medical Research and Development (AMED) JP19gk0110039：JP21tm0424601The Japan Agency for Medical Research and Development (AMED) JP21tm0124005
6 · The paper itself

Abstract

backgroundStudies investigating whether respiratory syncytial virus (RSV) infection, non-RSV respiratory infections, respiratory-related disorders, and non-respiratory-related disorders are associated with subsequent wheezing are limited in Japan. We aimed to elucidate the relationship between hospitalization for RSV infection, non-RSV respiratory infections, respiratory-related disorders, as well as non-respiratory-related disorders and subsequence wheezing in Japanese children.

methodsThis study included 7340 children and was conducted under the TMM BirThree Cohort Study (Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study). Data was collected from birth records and questionnaires. We categorized hospitalization history into five categories: "no hospitalization," hospitalizations for "RSV infection," "non-RSV respiratory infections," "respiratory-related disorders," and "non-respiratory-related disorders." The association of the five categories with later wheezing at 3 years of age was evaluated using multivariable logistic regression analysis.

resultsAfter adjusting for covariates, an association was shown between hospitalization under 2 years of age and later wheezing (odds ratio [OR] = 2.78; 95% confidence interval [CI] = 1.97-3.88 for "RSV infection"; OR = 2.61; 95% CI = 1.44-4.57 for "non-RSV respiratory infections"; and OR = 3.33; 95% CI = 2.43-4.54 for "respiratory-related disorders").

conclusionHospitalization of children under 2 years of age for RSV infection as well as non-RSV respiratory infections and respiratory-related disorders were associated with subsequent wheezing.

Indexed as

HospitalizationRespiratory SoundsRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornJapanMaleRisk Factorsbirth cohortepidemiologyrespiratory syncytial virusRSVwheezing

Identifiers

PMID40415719
PMCPMC12104963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.