ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Multifaceted Role of Microbiota-Derived Indole-3-Acetic Acid in Human Diseases and Its Potential Clinical Application.
Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Compound probiotics alleviateVirulence · 2026Article
- Oral Butyrate Reduces Progression of Kidney Damage in an L-NAME-Induced Diabetic Kidney Disease Mouse Model.Diabetes, obesity & metabolism · 2026Article
- Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte-to-DC Differentiation Via Microbiota-Associated IAA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ABCG2 transporter: Structural and functional associations with gout (Review).International journal of molecular medicine · 2026Review
- Phytochemical Characterization of Extracts From Aesculus hippocastanum L. Seeds and Quantification of Saponins Using HPLC-DAD and a Novel Tensiometric Approach.Chemistry & biodiversity · 2026Article
- Microbiota-Immune Crosstalk in Pneumonia and Acute Lung Injury: Mechanisms, Evidence, and Therapeutic Opportunities.Microorganisms · 2026Review
- Gut Microbiota and Atherosclerotic Plaque Instability: Cellular and Molecular Mechanisms.International journal of molecular sciences · 2026Review
- Auxin biosynthesis and signaling drive virulence and plant adaptation in Dickeya dadantii.PLoS pathogens · 2026Article
- Breaking the Efflux Barrier: P-Glycoprotein and Emerging Strategies to Overcome Multidrug Resistance in Cancer.Cancers · 2026Review
- Indole-3-acetic acid promotes differentiation while suppressing proliferation in human intestinal epithelial cells.Human cell · 2026Article
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Mycobacterium tuberculosis infection disrupts gut and respiratory microbial communities and networks with incomplete restoration after two months of treatment.Gut pathogens · 2026Article
- Phytochemical Diversity, Nutritional Values, and Biological Properties ofFood science & nutrition · 2026Review
- Stage-specific gut microbial restructuring drives estrous transition in rabbits.Animal bioscience · 2026Article
- Fecal microbiota transplantation plus immunotherapy in metastatic renal cell carcinoma: the phase 1 PERFORM trial.Nature medicine · 2026Article
- Physiological interplay among obesity, male fertility, and aryl hydrocarbon receptor in human and mice: A mini review.Open veterinary journal · 2026Review
- Effects of Galacto-Oligosaccharide Supplementation on Cecal Microbiota, Phospholipid and Aromatic Amino Acid Metabolism in Mice.Microorganisms · 2026Article
- Indole-acetaldehyde from Rothia mucilaginosa activates the PXR/NRF2 axis to enhance alveolar macrophage phagocytosis and protect against ARDS.Respiratory research · 2026Article
- Gut microbiota-host adaptive immune interactions in type 2 diabetes mellitus: mechanisms, disease progression, and microbiota-based therapeutic strategies.Frontiers in microbiology · 2026Review
- The therapeutic potential of botanicals: how medicinal plants targeting autophagy can reverse metabolic-associated fatty liver disease.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Indole-3-acetic acid (IAA) is recognized as a common plant growth hormone. It is also detectable in mammals, as it can be produced by gut microbiota in the gut. Current research works have shown that IAA is a multifaceted compound with significant consequences for several physiological and pathological processes. Higher levels of IAA occur in chronic kidney disease because decreased renal clearance contributes to cardiovascular and liver dysfunction. In contrast, IAA demonstrates protective effects by modulating oxidative stress, inflammation, and lipid metabolism in nonalcoholic fatty liver disease. IAA also shows potential therapeutic benefits in lung disorders such as acute lung injury, pulmonary fibrosis, and chronic obstructive pulmonary disease. Furthermore, IAA shows potential as an adjunct in cancer therapy, where it synergizes with chemotherapy regimens by endorsing oxidative stress and autophagy. Beyond cancer-related applications and metabolic disorders, IAA's role in neuroinflammation, mainly in conditions such as sepsis-associated encephalopathy and depression, underscores its potential as a therapeutic agent targeting the gut-brain axis. Furthermore, IAA is a potent oral hypoglycemic agent with mitigating effects on metabolic disorders associated with obesity and diabetes. This review provides an overview of the diverse roles of IAA in disease pathophysiology, its therapeutic promise, and the need for further research to better understand its mechanistic pathways. Understanding these complex effects could pave the way for novel microbiota-based therapies to address a range of chronic diseases and improve patient outcomes.
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