ArticleThe journal of international advanced otology2025
Middle Ear Transfer Function in Acromegaly Patients.
Article in The journal of international advanced otology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcromegaly is a rare disorder in which growth hormone is secreted uncontrollably by the pituitary gland. Considering the risk of pathological effects of acromegaly on middle ear (ME) transfer function and hearing, we aimed to investigate the ME transfer functions of acromegaly patients who underwent transsphenoidal surgery using wide-band tympanometry (WBT) in this study.
methodsPure tone audiometry (PTA), 226 Hz probe-tone acoustic immitancemetry, and WBT were performed on all participants. Twenty-eight patients with acromegaly and 29 healthy subjects were included in the current study.
resultsThe mean age of the acromegaly group (11 males, 17 females) was 49.25 ± 9.57 years, and that of the healthy controls (13 males, 16 females) was 45 ± 10.02 years. The PTA means of the acromegaly and healthy groups were between normal limits, but the mean of the acromegaly group (20.73 ± 10.95) was significantly worse than that of the healthy group (12.02 ± 6.67, P=.000). The WBT non-pressurized and pressurized absorbance values of the acromegaly and healthy groups did not show statistically significant differences. The equivalent ear canal volumes at 1000 Hz (P=.041) and the equivalent ear canal volume measured by averaging the WBT (P=.023) of the acromegaly group were larger than those of the healthy controls.
conclusionThe investigation revealed that the equivalent ear canal volumes were statistically significantly higher in patients with acromegaly. However, this did not impact the ME transfer function.
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