Evidence map›Paper›PMID 40415439›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[WW domain-containing ubiquitin E3 ligase 1 regulates immune infiltration in tumor microenvironment of ovarian cancer].

Xiaojuan Guo, Ruijuan DU, Liping Chen, Kelei Guo, Biao Zhou, Hua Bian, Li Han

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaojuan GuoZhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang 473004, China.
Ruijuan DUZhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang 473004, China.
Liping ChenZhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang 473004, China.
Kelei GuoZhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang 473004, China.
Biao ZhouZhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang 473004, China.
Hua BianZhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang 473004, China.
Li HanZhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang 473004, China.

Funding

National Natural Science Foundation of China 82074076
6 · The paper itself

Abstract

objectivesTo explore the association of the expression of WW domain-containing ubiquitin E3 ligase 1 (WWP1) with immune infiltration in tumor microenvironment (TME) of ovarian cancer.

methodsOvarian cancer patient data from The Cancer Genome Atlas (TCGA) were used to analyze the association of WWP1 expression with patient prognosis. TISCH2 was utilized to analyze the changes in immune cell subtypes in TME of metastatic tumor and after chemotherapy. The impact of WWP1 on immune cell infiltration, somatic copy number alterations of WWP1 and evolution of immune cell subtypes was evaluated using TIMER and TIGER pseudo-time analysis. A deep learning model was used to analyze TCGA pathological images to investigate the effect of WWP1 on TME of ovarian cancer. RNA-seq analysis was conducted to identify the differentially expressed genes in WWP1-overexpressing SKOV3 cells and validate immune infiltration. Multicolor immunofluorescence assay was used to analyze the immune markers in SKOV3 and SKOV3/DDP cell xenografts in nude mice.

resultsThe patients with high WWP1 expression levels had significantly lower overall survival rate (

conclusionsWWP1 may serve as a prognostic biomarker and a potential target for immune regulation in the TME of ovarian cancer.

Indexed as

Ovarian NeoplasmsTumor MicroenvironmentUbiquitin-Protein LigasesAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMiceMice, NudePrognosisUbiquitin-Protein LigasesWWP1 protein, humanimmune infiltrationovarian cancertumor microenvironmentWW domain-containing ubiquitin E3 ligase 1

Identifiers

PMID40415439
PMCPMC12104748

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