Evidence map›Paper›PMID 40415434›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Orexin-A promotes motor function recovery of rats with spinal cord injury by regulating ionotropic glutamate receptors].

Guanglü He, Wanyu Chu, Yan Li, Xin Sheng, Hao Luo, Aiping Xu, Mingjie Bian, Huanhuan Zhang, Mengya Wang, Chao Zheng

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guanglü HeNeurobiology Laboratory, 2Psychophysiology Laboratory, 3Cell Electrophysiology Laboratory, Institute of Physiological Sciences, Wannan Medical College, Wuhu 241002, China.
Wanyu ChuNeurobiology Laboratory, 2Psychophysiology Laboratory, 3Cell Electrophysiology Laboratory, Institute of Physiological Sciences, Wannan Medical College, Wuhu 241002, China.
Yan LiNeurobiology Laboratory, 2Psychophysiology Laboratory, 3Cell Electrophysiology Laboratory, Institute of Physiological Sciences, Wannan Medical College, Wuhu 241002, China.
Xin ShengNeurobiology Laboratory, 2Psychophysiology Laboratory, 3Cell Electrophysiology Laboratory, Institute of Physiological Sciences, Wannan Medical College, Wuhu 241002, China.
Hao Luo
Aiping Xu
Mingjie Bian
Huanhuan Zhang
Mengya Wang
Chao ZhengNeurobiology Laboratory, 2Psychophysiology Laboratory, 3Cell Electrophysiology Laboratory, Institute of Physiological Sciences, Wannan Medical College, Wuhu 241002, China.

Funding

National Natural Science Foundation of China 31200828
6 · The paper itself

Abstract

objectivesTo investigate the effect of orexin-A-mediated regulation of ionotropic glutamate receptors for promoting motor function recovery in rats with spinal cord injury (SCI).

methodsThirty-six newborn SD rats (aged 7-14 days) were randomized into 6 groups (

resultsAt 3 and 7 days after SCI, the orexin-A-treated rats showed significantly higher BBB scores and grip tilt angles than those with other interventions. Compared with those treated with DNQX alone, the rats receiving the combined treatment with orexin and DNQX had significantly higher BBB scores and grip tilt angles on day 7 after PCI. In the patch-clamp experiment, the ventral horn neurons from SCI rat models exhibited obviously higher reversal potential and greater rise slope of glutamate current with shorter decay time than those from sham-operated and orexin-treated rats.

conclusionsOrexin-A promotes motor function recovery in rats after SCI possibly by improving the function of the ionotropic glutamate receptors.

Indexed as

Intracellular Signaling Peptides and ProteinsNeuropeptidesReceptors, Ionotropic GlutamateRecovery of FunctionSpinal Cord InjuriesAnimalsAnimals, NewbornFemaleMaleOrexinsRatsRats, Sprague-DawleyIntracellular Signaling Peptides and ProteinsNeuropeptidesOrexinsReceptors, Ionotropic Glutamateionotropic glutamate receptororexin-Apatch-clamp recordingspinal cord injuryspinal cord ventral horn neurons

Identifiers

PMID40415434
PMCPMC12104742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.