Evidence map›Paper›PMID 40415427›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Enriched environment reduces pyramidal neuron excitability in the anterior cingulate cortex to alleviate restraint stress-induced anxiety-like behaviors in mice].

Changfeng Chen, Qin Fang, Yinhuan Gao, Liecheng Wang, Lei Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Changfeng ChenSchool of Basic Medicine Sciences, Anhui Medical University, Hefei 230032, China.
Qin FangSchool of Basic Medicine Sciences, Anhui Medical University, Hefei 230032, China.
Yinhuan GaoSchool of Basic Medicine Sciences, Anhui Medical University, Hefei 230032, China.
Liecheng WangSchool of Basic Medicine Sciences, Anhui Medical University, Hefei 230032, China.
Lei ChenDepartment of Pharmay, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the mechanism by which the pyramidal neurons of the anterior cingulate cortex (ACC) modulate the effects of enriched environment (EE) for relieving anxiety-like behaviors in mice.

methodsC57BL/6J mice were randomly divided into control group, restraint stress (RS) group, and RS+EE group (

resultsBehavioral tests showed obvious anxiety-like behaviors in RS mice, and such behavioral changes were significantly improved in RS+EE mice. Immunofluorescence staining revealed significantly increased c-Fos expression in the ACC in RS mice but lowered c-Fos expression in RS+EE group. Compared with the control mice, the RS mice showed increased action potential firing rate of Pyn

conclusionsEE reduces excitability of Pyn

Indexed as

AnxietyEnvironmentGyrus CinguliPyramidal CellsStress, PsychologicalAnimalsBehavior, AnimalExcitatory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-fosRestraint, PhysicalProto-Oncogene Proteins c-fosanterior cingulate cortexanxietyenriched environmentexcitabilitypyramidal neuron

Identifiers

PMID40415427
PMCPMC12104738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.