Evidence map›Paper›PMID 40415402›Full record

ArticleJournal of child neurology2025

Idiopathic Optic Perineuritis in a Pediatric Patient.

Cara Miller, NgocHanh H Vu, Richard B Carozza

Abstract readCase Reports
In one paragraph

Article in Journal of child neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cara MillerDepartment of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1986-8788
NgocHanh H VuDepartment of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0005-1596-1036
Richard B CarozzaDepartment of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-8727-3527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optic perineuritis is an inflammatory disorder of the optic nerve sheath, presenting with visual deficits, dyschromatopsia, and pain with extraocular movement, often confused with optic neuritis. Most cases are believed to be idiopathic but can be associated with autoimmune, infectious, and neoplastic etiologies. Treatment involves corticosteroids, and when administered promptly has been associated with rapid recovery. Delays in treatment have been linked to poor visual outcomes. Few pediatric cases have been described. We report a teenager who presented with 2 months of unilateral visual loss and paracentral scotoma, found to have optic perineuritis. She was treated aggressively with high-dose corticosteroids, therapeutic plasma exchange, and intravenous immunoglobulin, but had limited symptomatic recovery attributable to delays in seeking treatment. Optic perineuritis is rare in children but should be included in the differential for visual deficits, especially as delayed treatment is associated with irreversible visual loss. Further studies are needed for children to better identify underlying causes and establish consistent treatment paradigms.

Indexed as

Optic NeuritisAdolescentFemaleHumansMagnetic Resonance Imagingneuroimmunologyneuroophthalmologypediatrics

Identifiers

PMID40415402
PMCPMC12508487

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.