ArticleThe Journal of international medical research2025
Lactate alleviates trigeminal neuralgia symptoms in mice by suppressing neuroinflammation.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
ObjectivesTrigeminal neuralgia is a neuropathic pain syndrome that undesirably affects patient's quality of life. Lactate exerts extensive pathophysiological effects on the brain; however, it remains unclear whether lactate improves trigeminal neuralgia symptoms as well as the underlying mechanisms.MethodsIn our study, unilateral constriction of the infraorbital nerve was performed to establish a mouse model of trigeminal neuralgia. Conditional knockout of the astrocyte-specific lactate dehydrogenase gene was performed to decrease brain exposure to lactate. The behavioral changes were observed and the pain thresholds were detected via von Frey tests at 1, 5, 10, 15, and 30 days after surgery to evaluate the impact of lactate on trigeminal neuralgia. Intracerebroventricular injection of L-lactate was administered to evaluate the biological function of lactate in our model.ResultsWe revealed that lactate levels in the spinal trigeminal nucleus were elevated by approximately 2.5-fold (3.63 vs. 1.43 µmol/g) after surgery, which remained elevated for at least 30 days. This shift in lactate levels appeared to be independent of peripheral circulation, as plasma lactate levels remained unaltered until 30 days after surgery. Increased lactate exposure alleviated trigeminal neuralgia symptoms after the surgery. Mechanistically, lactate suppressed reactive oxygen species production and neuroinflammation.ConclusionsLactate may alleviate trigeminal neuralgia symptoms in mice by suppressing neuroinflammation.
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