ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Respiratory center function in patients under adaptive servoventilation: etiology and outcome.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
STUDY
objectivesCentral sleep apnea (CSA) is a sleep disorder characterized by instability in the respiratory center's function, leading to an excessive ventilatory response. The most effective treatment for these patients is adaptive servoventilation (ASV). We hypothesize that individuals with CSA may exhibit hyperresponsiveness of the respiratory center, and ASV treatment could normalize its function. We aimed to measure the ventilatory response to hypercapnia and its relationship with the outcomes following ASV treatment.
methodsA prospective study with repeated measurements was conducted on patients with CSA treated with ASV. A ventilatory response to a hypercapnia test was performed using p0.1/pEtCO
resultsWe analyzed 46 participants, 82% male. The apnea-hypopnea index was 47 events/h (23), and the central apnea-hypopnea index was 27 events/h (12). The initial p0.1/pEtCO
conclusionsVentilatory response to hypercapnia in patients with CSA and ASV treatment could differentiate phenotypes and impact therapeutic decisions. CITATION: Posada IM-G, Álvarez RF, Ortiz Reyes A, et al. Respiratory center function in patients under adaptive servoventilation: etiology and outcome.
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