Evidence map›Paper›PMID 40415340›Full record

ArticleJournal of proteome research2025

MultiOmicsAgent: Guided Extreme Gradient-Boosted Decision Trees-Based Approaches for Biomarker-Candidate Discovery in Multiomics Data.

Jens Settelmeier, Sandra Goetze, Julia Boshart, Jianbo Fu, Amanda Khoo, Sebastian N Steiner, Martin Gesell, Jacqueline Hammer, Peter J Schüffler, Diyora Salimova and 2 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jens SettelmeierInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.ORCID 0000-0001-5885-9465
Sandra GoetzeInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Julia BoshartInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Jianbo FuInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Amanda KhooInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Sebastian N SteinerInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Martin GesellInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Jacqueline HammerInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Peter J SchüfflerInstitute of Pathology, TUM School of Medicine and Health, Technical University of Munich, Munich 81675, Germany.ORCID 0000-0002-1353-8921
Diyora SalimovaDepartment for Applied Mathematics, Albert-Ludwigs-University of Freiburg, Freiburg 79104, Germany.
Patrick G A PedrioliInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.
Bernd WollscheidInstitute of Translational Medicine at the Department of Health Sciences and Technology, ETH, Zurich 8093, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MultiOmicsAgent (MOAgent) is an innovative, Python-based open-source tool for biomarker discovery, utilizing machine learning techniques, specifically extreme gradient-boosted decision trees, to process multiomics data. With its cross-platform compatibility, user-oriented graphical interface, and well-documented API, MOAgent not only meets the needs of both coding professionals and those new to machine learning but also addresses common data analysis challenges like normalization, data incompleteness, class imbalances and data leakage between disjoint data splits. MOAgent's guided data analysis strategy opens up data-driven insights from digitized clinical biospecimen cohorts, making advanced data analysis accessible and reliable for a wide audience.

Indexed as

BiomarkersDecision TreesProteomicsSoftwareHumansMachine LearningMultiomicsBiomarkersbiomarker discoveryextreme gradient-boosted decision treesmachine learningmultiomicsPython tool

Identifiers

PMID40415340
PMCPMC12150338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.