Evidence map›Paper›PMID 40415263›Full record

SynthesisJournal of oral rehabilitation2025

Effectiveness of Resistance Training of Masticatory Muscles for Patients With Temporomandibular Disorders: A Systematic Review.

Giacomo Asquini, Giulia Pisacane, Filippo Maselli, Firas Mourad, Paolo Bizzarri, Edoardo Balli, Cecilia Bagnoli, Anna Manzari, Marco Pernici, Andrea Giusti and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of oral rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giacomo AsquiniCentre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0003-1683-7203
Giulia PisacaneDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Filippo MaselliDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Firas MouradDepartment of Health, LUNEX University of Applied Sciences, Differdange, Luxembourg.
Paolo BizzarriDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Edoardo BalliDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Cecilia BagnoliDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Anna ManzariDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Marco PerniciDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Andrea GiustiDepartment of Human Neurosciences, University of Roma "La Sapienza", Rome, Italy.
Deborah FallaCentre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0003-1689-6190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence supports the use of exercise for patients with temporomandibular disorders (TMDs). However, previous studies have mainly focused on combined treatment strategies or undefined exercise modalities.

objectiveThis systematic review aims to evaluate the effectiveness of Resistance Training (RT) as a standalone treatment for managing pain and improving neuromuscular performance in individuals with TMDs.

methodsThis systematic review followed a pre-established and published protocol, which was registered with PROSPERO (CRD42023476269). The literature search was conducted from March 1st 2024 to March 31st 2024 via the following electronic databases: MEDLINE (OVID interface), EMBASE (OVID interface), SCOPUS, Web of Science, PubMed, and Cochrane Central Register of Controlled Trials (CENTRAL). Randomised controlled trials or nonrandomised studies of interventions were included when they compared the effect of RT targeting masticatory muscles on pain, neuromuscular performance, and maximum mouth opening in patients with TMDs versus other treatment modalities. Two independent reviewers screened articles for inclusion, extracted data, assessed the risk of bias using the revised Cochrane risk of bias tool for randomised trials and evaluated the overall quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.

resultsFrom an initial 2177 articles, only three met the inclusion criteria and involved 108 participants. All the included studies demonstrated a decrease in pain intensity and an improvement in neuromuscular performance following RT, even if the superiority of RT over other interventions remains uncertain. However, the combination of moderate risk of bias, significant heterogeneity and small sample sizes resulted in a very low quality of evidence.

conclusionsClinicians managing patients with TMDs should consider RT as an effective, conservative option in conjunction with other treatment modalities. Future methodologically robust studies with large sample sizes and clearly defined exercise protocols are needed to investigate the role of RT for reducing TMD-related pain by increasing load tolerance and addressing potential bruxism-related muscle overload.

Indexed as

Facial PainMasticatory MusclesResistance TrainingTemporomandibular Joint DisordersHumansRandomized Controlled Trials as TopicTreatment Outcomeexercisemasticatory musclepainphysical therapyresistance trainingtemporomandibular disordertemporomandibular joint

Identifiers

PMID40415263
PMCPMC12408958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.