Evidence map›Paper›PMID 40415141›Full record

SynthesisJournal of thrombosis and thrombolysis2025

Antiplatelet therapy following conservatively managed spontaneous coronary artery dissection.

Madeline K Mahowald, Luis Ortega-Paz, Claudio Laudani, Dominick J Angiolillo

Abstract readReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madeline K MahowaldDivision of Cardiology, University of Florida College of Medicine, Jacksonville, FL, USA. madeline.mahowald@jax.ufl.edu.ORCID http://orcid.org/0000-0003-1685-6690
Luis Ortega-PazDivision of Cardiology, University of Florida College of Medicine, Jacksonville, FL, USA.
Claudio LaudaniDivision of Cardiology, University of Florida College of Medicine, Jacksonville, FL, USA.
Dominick J AngiolilloDivision of Cardiology, University of Florida College of Medicine, Jacksonville, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous coronary artery dissection (SCAD) is a relatively uncommon but increasingly recognized etiology of acute coronary syndrome (ACS). Conservative management is generally recommended, but optimal medical therapy is unknown. The majority of patients are discharged on dual antiplatelet therapy consisting of aspirin and a P2Y12 inhibitor based on trials and guidelines developed for ACS caused by plaque rupture and subsequent platelet activation and aggregation. Observational trials have shown conflicting results on the effects of antiplatelet therapy on major adverse cardiac events after SCAD. This manuscript provides a review of the available data, including a meta- analysis, and offers recommendations for antiplatelet therapy after conservatively managed SCAD in clinical practice.

Indexed as

Acute Coronary SyndromeConservative TreatmentCoronary Vessel AnomaliesPlatelet Aggregation InhibitorsVascular DiseasesAspirinDual Anti-Platelet TherapyHumansPurinergic P2Y Receptor AntagonistsAspirinPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsAcute coronary syndromeAntiplatelet therapySpontaneous coronary artery dissection

Identifiers

PMID40415141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.