Evidence map›Paper›PMID 40415044›Full record

ReviewWorld journal of microbiology & biotechnology2025

Research progress and development prospects of microbial synthesis of ergothioneine.

Zhixiao Lei, Yifan Feng, Wenming Zhang, Yujia Jiang, Minjiao Chen, Wankui Jiang, Fengxue Xin

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. EngineeringMicroorganisms · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhixiao Lei *State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, P. R. China.
Yifan Feng *State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, P. R. China.
Wenming ZhangState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, P. R. China.
Yujia JiangState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, P. R. China.
Minjiao ChenState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, P. R. China.
Wankui JiangState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, P. R. China. jiangwankui@njtech.edu.cn.
Fengxue XinState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, P. R. China. xinfengxue@njtech.edu.cn.

Funding

Jiangsu Agriculture Science and Technology Independent Innovation Fund Project JASTIF, CX(24)3085National Key R&D Program of China 2023YFC3403500National Natural Science Foundation of China 22408164Shandong Taishan Industrial Experts Program 202306155State Key Laboratory of Materials-Oriented Chemical Engineering No. SKL-MCE-23A10
6 · The paper itself

Abstract

Ergothioneine (Egt) is a rare sulfur-containing amino acid widely distributed in edible fungi and bacteria. As a natural antioxidant, Egt has demonstrated significant application potential in the food, pharmaceutical, and cosmetic industries. However, conventional Egt production predominantly relies on chemical synthesis and biological extraction methods, which suffer from low titers and cannot meet the escalating market demand. With advances in synthetic biology, genetic engineering of suitable microbial chassis strains coupled with fermentation process optimization has emerged as a research hotspot for enhancing Egt biosynthesis efficiency. This review systematically examines Egt's applications, metabolic pathways, microbial synthesis strategies, and fermentation optimization approaches, while also prospecting future research directions and technical challenges in Egt production.

Indexed as

BacteriaErgothioneineFungiAntioxidantsBiosynthetic PathwaysFermentationMetabolic EngineeringMetabolic Networks and PathwaysSynthetic BiologyAntioxidantsErgothioneineErgothioneineFermentation engineeringGenetic engineeringSynthetic biology

Identifiers

PMID40415044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.