ArticleClinical oral investigations2025
Growth pattern prediction of maxillary segments in infants with unilateral cleft lip and palate: a prospective in vivo study.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the study was to identify the best prediction model for the growth pattern of the maxillary segments of infants with unilateral cleft lip and palate post birth and prior to the primary surgical cleft closure. MATERIALS AND
methods195 digital maxillary models of 50 infants with unilateral cleft lip and palate were collected during their preoperative alveolar molding therapy period. Intraoral scans were taken shortly after birth, at the monthly checkups and just before the surgical cleft closure at approximately 6 months of age. Surface measurements of maxillary segments were conducted using the diagnostic program OnyxCeph³™. For identifying the best fit for the growth pattern, mixed-effects regression models (fractional polynomials and B-splines) with the surface measurement as dependent variable, patient age (days) as predictor and the patient as random effect were fitted to the data. The best fit was selected according to the Akaike Information Criterium. A likelihood ratio test was performed for comparing the selected model with the intercept-only model.
resultsThe linear regression with mixed effects model showed the best fit for the total area, the area of the large segment and the area of the small segment. A highly significant association between the surface area and patient age was observed (p < 0.001). An increase of the area with time was estimated at 2.88 mm
conclusionThe growth pattern for the maxillary segments of patients with unilateral cleft lip and palate in the preoperative period can be best predicted by using a linear regression model. The growth curve model developed by the present study can be used in future treatment planning of patients with unilateral cleft lip and palate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.