Evidence map›Paper›PMID 40414997›Full record

ArticleScientific reports2025

Corchorus olitorius exhibits antiproliferative potential supported by metabolic profiling and integrative biological analyses.

Salma Sameh, Maha R A Abdollah, Ahmed M Elissawy, Eman Al-Sayed, Rola M Labib, Lan Ye, Fang-Rong Chang, Abdel Nasser B Singab

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Anti-Inflammation and Anti-Hypersensitivity Effects ofPreventive nutrition and food science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salma SamehDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt.
Maha R A AbdollahDepartment of Pharmacology, Faculty of Pharmacy, The British University in Egypt, El Sherouk City, Egypt.
Ahmed M ElissawyDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt.
Eman Al-SayedDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt.
Rola M LabibDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt.
Lan YeCancer Centre, the Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, 250033, Shandong, China.
Fang-Rong ChangSchool of Pharmacy and Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Abdel Nasser B SingabDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, 11566, Egypt. AbdelnasserSingab@pharma.asu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herbal nutraceuticals could be employed as alternative or complementary routes for alleviating cancer. Corchorus olitorius (Malvaceae) was employed traditionally in the management of tumors. The study aimed to investigate the antiproliferative activity of C. olitorius leaves. In vitro cytotoxic and anti-angiogenic activities of C. olitorius were estimated. The bioactive fraction was subjected to in vivo study on BALB/ c female mice using Ehrlich Ascites Carcinoma model. UPLC-ESI-MS/MS analysis was done to determine the phytometabolites followed by in silico studies on the major identified compounds. The bioactive fraction possessed potent in vitro activity against A549 cells with IC

Indexed as

Antineoplastic Agents, PhytogenicCell ProliferationMetabolomePlant ExtractsA549 CellsAngiogenesis InhibitorsAnimalsCarcinoma, Ehrlich TumorCell Line, TumorFemaleHumansMetabolomicsMiceMice, Inbred BALB CPlant LeavesTandem Mass SpectrometryAngiogenesis InhibitorsAntineoplastic Agents, PhytogenicPlant ExtractsAnti-angiogenicAntiproliferativeCorchorusHerbal nutraceuticalsMalvaceaeUPLC-ESI-MS/MS

Identifiers

PMID40414997
PMCPMC12104385

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.