Evidence map›Paper›PMID 40414994›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2025

PSMA radioligand uptake correlates with PSMA expression in high-grade glioma and brain metastasis: insights from a prospective PET-MRI guided multiregional biopsy study.

Ilanah J Pruis, Vera van Dis, Sybren L N Maas, Rutger K Balvers, Thierry P P van den Bosch, Marcel Segbers, Sophie E M Veldhuijzen van Zanten

Abstract readClinical Trial
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Quantitative [Molecular imaging and biology · 2026
    Trial
  2. Molecular Brain Tumor Imaging Beyond [AJR. American journal of roentgenology · 2026
    Review
  3. Review
  4. Synthesis and preclinical evaluation of aEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ilanah J PruisDepartment of Radiology and Nuclear Medicine, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Vera van DisBrain Tumour Centre, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Sybren L N MaasBrain Tumour Centre, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Rutger K BalversBrain Tumour Centre, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Thierry P P van den BoschDepartment of Pathology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Marcel SegbersDepartment of Radiology and Nuclear Medicine, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Sophie E M Veldhuijzen van ZantenDepartment of Radiology and Nuclear Medicine, University Medical Centre Rotterdam, Rotterdam, The Netherlands. s.veldhuijzenvanzanten@erasmusmc.nl.ORCID 0000-0002-3888-0977

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProstate-specific membrane antigen (PSMA) is a potential target for radioligand therapy (RLT) in neuro-oncology. This study investigates the direct relation between [

methodsTwelve patients with HGG (glioblastoma n = 6, oligodendroglioma n = 1), or BM (lung- n = 4, breast cancer n = 1), underwent PET-MRI after intravenous [

resultsAll patients showed [

conclusionPSMA expression in brain tumours is predominately vascular, which likely explains why microvascular (rather than tumour cell) PSMA expression correlates with [

Indexed as

Antigens, SurfaceBrain NeoplasmsEdetic AcidGene Expression Regulation, NeoplasticGliomaGlutamate Carboxypeptidase IIMagnetic Resonance ImagingPositron-Emission TomographyAdultAgedBiological TransportFemaleGallium IsotopesGallium RadioisotopesHumansImage-Guided BiopsyAntigens, SurfaceEdetic AcidFOLH1 protein, humangallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesGlutamate Carboxypeptidase IIImage-guided biopsy samplingImmunohistochemistryMalignant brain tumourPET-MRIProstate-specific membrane antigen

Identifiers

PMID40414994
PMCPMC12589371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.