ArticleInfectious agents and cancer2025
High-risk HPV genotypes in women with abnormal cytology: a 12-year retrospective study.
Article in Infectious agents and cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Epidemiology of Human Papillomavirus in the Middle East and North Africa: A Review of Genotypic Prevalence, Vaccination Challenges, and Non-Cervical Clinical Outcomes.Diseases (Basel, Switzerland) · 2026Review
- Risk-Based Triage Using Cytology and HPV Genotyping to Reduce Unnecessary Colposcopy: A Real-World Cross-Sectional Study.Biomedicines · 2026Article
- Article
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6 authors.
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Abstract
BACKGROUND AND
aimPersistent infections with high-risk human papillomavirus (HR-HPV) are linked to cervical cancer progression. The prevalence and distribution of HPV genotypes vary across regions and lesion severity. Comprehensive data on HPV genotype distribution among Iranian women is limited. This study investigates the distribution of HR-HPV genotypes in women with abnormal cytology in Qazvin province, northwest Iran, from 2007 to 2019. MATERIALS AND
methodsA total of 103 samples, including benign cases, Low-grade Squamous Intraepithelial Lesions (LSIL), High-grade Squamous Intraepithelial Lesions (HSIL), and Invasive Cervical Cancer (ICC), were analyzed using real-time PCR to detect HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 58, and 59.
resultsThe study revealed a high HPV prevalence (92.23%), with HPV-16 being the most common genotype (66.31%), followed by HPV-45 (49.47%), HPV-33 (41.05%), HPV-31(30.52%) and HPV-52 (23.15%). HPV-18 was detected only in 3 (3.15%) of cases. Of the HPV-positive samples, 82.11% had multiple infections, with HPV-16, HPV-33, and HPV-45 more prevalent in these cases. HPV-16 was significantly associated with severe lesions, particularly in ICC cases (92%, P = 0.007).
conclusionThese findings emphasize the role of HPV genotyping in assessing cervical lesion severity and oncogenic risk, highlighting HPV-16 as the dominant genotype across various lesion grades. The study suggests that HPV-33 and HPV-45 may also contribute significantly to cervical lesion progression.
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