ArticleDiabetology & metabolic syndrome2025
The relationship between hemoglobin glycation index and the risk of cardiovascular disease in populations with diabetes or prediabetes: a population-based cohort study.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- HbA1c-Based Metabolic Stratification: A Retrospective Study of Clinical and Biological Differences Across Normoglycemic, Prediabetic, and Diabetic Subjects.Diagnostics (Basel, Switzerland) · 2026Article
- Hemoglobin glycation index and prognosis after successful chronic total occlusion percutaneous coronary intervention: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Analysis of the Relationship Between Glycated Hemoglobin and Echocardiographic Parameters in Patients Without Diabetes: A Retrospective Study.Journal of clinical medicine · 2025Article
- The Association Between the Hemoglobin Glycation Index and Cardiometabolic Diseases: A Mini-Review.Journal of clinical hypertension (Greenwich, Conn.) · 2025Review
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4 authors.
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Abstract
objectiveThe relationship between Glycated Hemoglobin Index (HGI) and cardiovascular disease (CVD) risk in individuals with diabetes or prediabetes remains unclear. Therefore, this study aims to investigate the relationship between baseline HGI and CVD risk in U.S. adults with diabetes or prediabetes.
methodsThis study analyzed data from 10,889 diabetic or prediabetic participants from the National Health and Nutrition Examination Survey (NHANES). Weighted multivariable regression analysis and subgroup analyses were employed to assess the relationship between HGI and CVD risk. Restricted cubic splines were used to explore nonlinear associations, along with threshold effect analysis and subgroup analyses.
resultsA total of 10,889 participants (mean age 52.82 years, 54.57% male) were included in this study. We observed a U-shaped relationship between HGI and the risk of cardiovascular disease (CVD) (P nonlinear < 0.0001), heart attack (P nonlinear = 0.0006), and congestive heart failure (CHF) (P nonlinear = 0.0001). The inflection points for HGI concerning CVD, heart attack, and CHF were - 0.140, -0.447, and - 0.140, respectively. When baseline HGI exceeded these thresholds, each unit increase in HGI was significantly associated with higher risks of CVD (OR: 1.34, 95% CI: 1.23-1.48), heart attack(OR: 1.34, 95% CI: 1.20-1.51), and CHF (OR: 1.39, 95% CI: 1.22-1.58).Subgroup analysis revealed significant differences in CHF risk associated with HGI across racial groups (interaction P = 0.03).
conclusionIn individuals with diabetes and prediabetes, HGI displays a U-shaped relationship with CVD, heart attack, and CHF risks, with threshold values of -0.14, -0.45, and - 0.14, respectively. HGI may serve as a more effective indicator for identifying populations at early risk for cardiovascular disease.
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