Evidence map›Paper›PMID 40414845›Full record

ArticleJournal of nanobiotechnology2025

A lyophilizable LNP vaccine enables STING-reinforced postoperational adjuvant immunotherapy.

Yi Yang, Jiaxin Guo, Jialong Qi, Wenxia Deng, Jialin Hu, Muhammad Waqqas Hasan, Fei Deng, You Zhou, Zhengji Song, Wei Deng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yi Yang *The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China.ORCID http://orcid.org/0009-0006-9634-6605
Jiaxin Guo *The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China.ORCID http://orcid.org/0009-0006-2267-2600
Jialong Qi *Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, P. R. China.ORCID http://orcid.org/0000-0001-6361-7479
Wenxia DengThe NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China.
Jialin HuThe NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China.
Muhammad Waqqas HasanThe NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China.ORCID http://orcid.org/0000-0001-8560-7714
Fei DengGraduate School of Biomedical Engineering, ARC Centre of Excellence in Nanoscale Biophotonics, Faculty of Engineering, UNSW Sydney, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-5606-0278
You ZhouThe NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China.ORCID http://orcid.org/0000-0002-0779-9519
Zhengji SongYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, P. R. China. song4715@163.com.
Wei DengSchool of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW, 2007, Australia. wei.deng@uts.edu.au.ORCID http://orcid.org/0000-0002-9413-0978
Wenjie ChenThe NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P. R. China. wenjie.chen1@hdr.mq.edu.au.ORCID http://orcid.org/0000-0001-9512-9664

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint blockade therapy (iCBT) has revolutionized cancer treatment, however, there is a low response rate, especially in treating postsurgical reoccurring tumors. Vaccine based immunotherapy can sensitize iCBT, but its development was largely hindered by inefficient delivery and high requirements of storage. In this study, the vaccine loaded with immunostimulant was employed to improve iCBT-based adjuvant postsurgical therapy. A lyophilized, antigen E7 peptide and manganese ion (Mn

Indexed as

Cancer VaccinesImmunotherapyMembrane ProteinsNanoparticlesAdjuvants, ImmunologicAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleFreeze DryingHumansImmune Checkpoint InhibitorsLiposomesManganeseMiceMice, Inbred C57BLAdjuvants, ImmunologicCancer VaccinesImmune Checkpoint InhibitorsLipid NanoparticlesLiposomesManganeseMembrane ProteinsSting1 protein, mouseSTING ProteinAdjuvant therapyiCBTLyophilizable LNP vaccineManganeseSTING

Identifiers

PMID40414845
PMCPMC12105125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.