Evidence map›Paper›PMID 40414700›Full record

ReviewAmerican journal of clinical pathology2025

A critical analysis of CellaVision systems in the modern hematology laboratory.

Brydon Panozzo, Jaineel Ramnarain, Song Chen, Hiu Lam Agnes Yuen, Maciej Tatarczuch, Shahla Vilcassim, Christopher Chang-Yew Leow, Chris Barnes

Abstract readReview
In one paragraph

Review in American journal of clinical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brydon PanozzoSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-9642-1720
Jaineel RamnarainAustralian Clinical Labs, Melbourne, Victoria, Australia.
Song ChenAustralian Clinical Labs, Melbourne, Victoria, Australia.
Hiu Lam Agnes YuenAustralian Clinical Labs, Melbourne, Victoria, Australia.
Maciej TatarczuchAustralian Clinical Labs, Melbourne, Victoria, Australia.
Shahla VilcassimAustralian Clinical Labs, Melbourne, Victoria, Australia.
Christopher Chang-Yew LeowAustralian Clinical Labs, Melbourne, Victoria, Australia.
Chris BarnesAustralian Clinical Labs, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis review aims to provide a comprehensive analysis of the current literature regarding the use of CellaVision digital morphology systems and to assess the emerging applications, their potential to supplement current diagnostic pathways, and-importantly-appreciate their practical and perceived limitations.

methodsA manual literature review was conducted to identify relevant journal articles and published abstracts as they relate to the application of CellaVision systems to hematology laboratory practice in human patients.

resultsCellaVision systems can characterize cellular morphology with overall a high degree of accuracy-in particular, for neutrophils; lymphocytes; and common red blood cell changes, including target cells. Challenges remain, however, with the detection of particular important findings, including immature granulocytes and red blood cell agglutination. The application of CellaVision systems to emerging areas such as telepathology and parasitology are evolving, with an increasing volume of literature highlighting the technology's utility.

conclusionCellaVision systems and associated digital technologies are poised to play an increasingly important role in hematology laboratories, with promises of enhanced accuracy and improved workflows. Several critical deficiencies highlight the necessity for continued research to support their transition into routine clinical practice.

Indexed as

HematologyImage Processing, Computer-AssistedLaboratories, ClinicalHumansCellaVisiondigital morphologytelepathology

Identifiers

PMID40414700
PMCPMC12378398

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.