ArticleBMJ open ophthalmology2025
Peripheral retinal irradiation with low-energy red light can effectively and safely delay the progression of myopia.
Article in BMJ open ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Significant Improvement in High Myopic Anisometropic Amblyopia Treated With Repeated Low-Level Red-Light (RLRL) Therapy: A Case Report.The American journal of case reports · 2026Article
- Effects of different powers of repeated low-level red light on form-deprivation myopia inhibition in guinea pigs.Scientific reports · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine whether peripheral retinal irradiation with low-energy red light can effectively and safely delay the progression of myopia.
methodsThe guinea pigs (age, 2 weeks) were used. The central or peripheral retina was exposed to red light for 3 min each at 9:00 AM and 5:00 PM daily. At day 28, examinations were performed to assess the condition of axial length, the cornea and lens, and the central choroid thickness. The ratio of axial length at a given time to the baseline axial length was used to assess the axial length growth.
resultsUnder the same energy density mode, illuminance (energy density) on the retina layer of peripheral irradiation is less than that of central irradiation. Under myopia induction, after 4 weeks of red light irradiation, the axial length ratios of the central and peripheral irradiation groups were 1.09±0.02 and 1.07±0.02, respectively, both significantly lower than the axial length ratio of 1.11±0.01 in the group with only myopia induction. Peripheral irradiation outperformed central irradiation in delaying axial elongation (p<0.05). Under the premise of myopia induction, peripheral irradiation but not central irradiation at 0.6 mW/cm² still delayed axial elongation. Both central and peripheral irradiation increased central choroidal thickness, with peripheral irradiation having a more pronounced effect.
conclusionPeripheral retinal irradiation with low-energy red light can effectively and safely slow axial growth while increasing central choroidal thickness. The follow-up period for the current study is 28 days, and the long-term safety of red light therapy for myopia necessitates further investigation.
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