Evidence map›Paper›PMID 40414302›Full record

ArticleThe Journal of nutrition2025

Placental Metabolism Is Linked to Prenatal Vitamin Supplement Use in the First Month of Pregnancy in the MARBLES Cohort.

Mariana Parenti, Rebecca J Schmidt, Daniel J Tancredi, Meghan Miller, Irva Hertz-Picciotto, Cheryl K Walker, Carolyn M Slupsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariana ParentiDepartment of Nutrition, University of California, Davis, CA, United States.
Rebecca J SchmidtDepartment of Public Health Sciences, University of California, Davis, CA, United States; MIND Institute, University of California, Davis, CA, United States.
Daniel J TancrediDepartment of Pediatrics, School of Medicine, University of California, Davis, CA, United States.
Meghan MillerMIND Institute, University of California, Davis, CA, United States; Department of Psychiatry & Behavioral Sciences, School of Medicine, University of California, Davis, CA, United States.
Irva Hertz-PicciottoDepartment of Public Health Sciences, University of California, Davis, CA, United States; MIND Institute, University of California, Davis, CA, United States.
Cheryl K WalkerMIND Institute, University of California, Davis, CA, United States; Department of Obstetrics & Gynecology, School of Medicine, University of California, Davis, CA, United States.
Carolyn M SlupskyDepartment of Nutrition, University of California, Davis, CA, United States; Department of Food Science and Technology, University of California, Davis, CA, United States. Electronic address: cslupsky@ucdavis.edu.

Funding

UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic MarkersR01ES020392 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, OZONOFF, SALLY · 2011 to 2015
$9.0M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CRAWLEY, JACQUELINE N · 2013 to 2019
$8.5M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
Environmental Influence on Infant Microbiome Development and ASD SymptomsR01ES028089 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, MILLS, DAVID ANDREW · 2016 to 2020
$3.6M
Folic Acid Prevention Pathways for ASD in High Risk FamiliesR01ES025574 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2015 to 2019
$3.1M
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESR24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany D. Chambers Butcher, Rebecca Jean Schmidt · 2017 to 2026
$2.3M
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESU24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAMBERS BUTCHER, BRITTANY D., SCHMIDT, REBECCA JEAN · 2023 to 2025
$1.2M
Metabolic and Microbiome Mechanisms Linking Gestational Phthalate Exposure with Child ASD RiskR21ES028129 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SLUPSKY, CAROLYN, WALKER, CHERYL KATHERINE · 2017 to 2018
$425k
NICHD NIH HHS U54 HD079125NIEHS NIH HHS P01 ES011269NIEHS NIH HHS R01 ES020392NIEHS NIH HHS R01 ES025574NIEHS NIH HHS R01 ES028089NIEHS NIH HHS R21 ES028129NIEHS NIH HHS R24 ES028533NIEHS NIH HHS T32 ES007059NIEHS NIH HHS U24 ES028533
6 · The paper itself

Abstract

backgroundThe first month of pregnancy is a key time in early developmental programming. Prenatal vitamin/mineral supplement use during the first month of pregnancy (PNVmo1) was associated with reduced risk of autism spectrum disorder (ASD) in the Markers of Autism Risk in Babies, Learning Early Signs (MARBLES) cohort.

objectivesWe aimed to evaluate the associations between PNVmo1, the placental and umbilical cord serum metabolomes, and the child's later neurodevelopmental outcome in the MARBLES pregnancy cohort.

methodsPlacental (n = 78) and umbilical cord serum (n = 132) metabolomes were investigated using

resultsAfter adjustment for covariates, permutational multivariate analysis of variance revealed that PNVmo1 was significantly (P < 0.05) associated with the placental and umbilical cord serum metabolomes. In the placenta, higher concentrations of amino acids were observed in the PNVmo1 group (false discovery rate <0.1). After adjustment for PNVmo1 and other covariates, permutational multivariate analysis of variance revealed a significant association (P < 0.05) between the placental metabolome and Non-TD outcome status. No associations were observed in the analyses of umbilical cord serum metabolism or with ASD outcome. We tested for but did not find evidence that the placental metabolome explained the relationship between PNVmo1 and Non-TD outcome in an exploratory mediation analysis.

conclusionsThese findings suggest that the placental metabolome could be sensitive to nutrient supplementation during the earliest stages of pregnancy.

Indexed as

Autism Spectrum DisorderDietary SupplementsPlacentaVitaminsAdultChild, PreschoolCohort StudiesFemaleFetal BloodHumansInfantMaleMetabolomePregnancyVitaminsmetabolomicsneurodevelopmentplacentaprenatal supplementationumbilical cord serum

Identifiers

PMID40414302
PMCPMC12673020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.