Evidence map›Paper›PMID 40414197›Full record

ReviewCardiorenal medicine2025

Cardiopulmonary Exercise Testing in Patients with Chronic Kidney Disease.

Nolan W Groninger, Drake E Dillman, Hunter Stafford, Monique Campos, Andrew R Coggan, Kenneth Lim

Abstract readReview
In one paragraph

Review in Cardiorenal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Cardiopulmonary Exercise Testing across Interdialytic Intervals in Hemodialysis Patients.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nolan W GroningerDivision of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA, ngroning@iu.edu.
Drake E DillmanDivision of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hunter StaffordDivision of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Monique CamposDivision of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Andrew R CogganDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Kenneth LimDivision of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

Redefining cardiovascular risk assessment in dialysis patients (ROCK-D) studyR01HL166747 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Kenneth Lim · 2023 to 2026
$3.0M
The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trialR33HL155858 · NHLBI · WASHINGTON UNIVERSITY · PI ANDREW R COGGAN, LINDA Ruth PETERSON · 2023 to 2026
$2.9M
NHLBI NIH HHS R01 HL166747NHLBI NIH HHS R33 HL155858
6 · The paper itself

Abstract

backgroundCardiopulmonary exercise testing (CPET) is an emerging tool in nephrology that has garnered significant interest among clinicians and investigators. SUMMARY: CPET technology enables the user to accurately assess cardiovascular functional capacity using an integrative approach, to identify multi-organ reserve capacities and interrogate pathophysiological mechanisms underpinning impaired exercise tolerance in patients with chronic kidney disease (CKD). These capabilities provide rationale for accumulating studies exploring the use of this existing technology for new applications in nephrology and to solve current clinical practice barriers. Examples of current clinical interest areas include its potential to help transform diagnostic approaches to cardiovascular complications in patients with CKD, to offer superior cardiovascular risk stratification and to provide a solution to current limitations of traditional resting endpoints in cardiorenal clinical trials. KEY MESSAGES: This article reviews the foundational principles, methodologic, and operational implementation of CPET in patients with CKD and those on dialysis.

Indexed as

Cardiovascular DiseasesExercise TestExercise ToleranceRenal Insufficiency, ChronicHumansRenal DialysisCardiopulmonary exercise testingCardiovascular diseaseCardiovascular functional capacityChronic kidney diseaseExercise capacity

Identifiers

PMID40414197
PMCPMC12224200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.