Evidence map›Paper›PMID 40414140›Full record

ReviewCurrent opinion in immunology2025

Unmet needs in autoimmune liver diseases.

Mirjam Kolev, Andreas E Kremer, Christiane Sokollik, Merill Eric Gershwin, Benedetta Terziroli Beretta-Piccoli, speakers of 4th Swiss Autoimmune Liver Disease Meeting

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Nor-ursodeoxycholic acid in hepatobiliary diseases: A narrative review.World journal of gastrointestinal pharmacology and therapeutics · 2026
    Review
  2. Review
  3. Autoantibodies in the follow-up of autoimmune hepatitis.Journal of translational autoimmunity · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mirjam KolevDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Andreas E KremerDepartment of Gastroenterology and Hepatology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.
Christiane SokollikDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital, Inselspital, University of Bern, 3010 Bern, Switzerland.
Merill Eric GershwinDivision of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California, USA.
Benedetta Terziroli Beretta-PiccoliEpatocentro Ticino, Lugano, Switzerland; Faculty of Medical Biosciences, Università della Svizzera Italiana, Switzerland; MowatLabs, Faculty of Life Sciences & Medicine, King's College London, King's College Hospital, London, UK; Servizio di Gastroenterologia ed Epatologia, Ente Ospedaliero Cantonale, Ospedale Civico, Lugano, Switzerland. Electronic address: benedetta.terziroli@usi.ch.
speakers of 4th Swiss Autoimmune Liver Disease Meeting

Funding

Alterations of aryl hydrocarbon receptor signaling in autoimmune hepatitisR01DK124408 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LONGHI, MARIA SERENA · 2020 to 2022
$1.2M
NIDDK NIH HHS R01 DK124408
6 · The paper itself

Abstract

Autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis are well-defined autoimmune liver diseases, the pathophysiology of which remains enigmatic. While major therapeutic advances have been achieved for many other autoimmune diseases, precision therapy for these diseases has lagged. For example, limited data exist on the use of innovative drugs targeting the immune system, such as monoclonal antibodies that block immune checkpoint, mRNA vaccines, the influence of infections, the microbiome, and drugs on loss of tolerance in liver autoimmunity. The knowledge on recent radiological techniques, on the expanding role of artificial intelligence in medicine, and on the relationship between the pediatric and adult phenotypes also urgently needs to be advanced in liver autoimmunity. Increased patient involvement focusing on individual symptom burden is also crucial for improving long-term quality of treatment. The fourth Swiss Autoimmune Liver Disease Meeting provided a unique interdisciplinary platform for experts and patients to discuss critical gaps. This opinion paper highlights the discussions on unmet needs and potential solutions in autoimmune liver diseases.

Indexed as

Autoimmune DiseasesHepatitis, AutoimmuneLiver DiseasesAnimalsAutoimmunityCholangitis, SclerosingHumans

Identifiers

PMID40414140
PMCPMC12744518

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.