ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025
Heart substructure exposure during left breast cancer radiotherapy: a dosimetric comparison between hybrid VMAT and 3DCRT in free breathing and deep inspiration breath hold (DIBH).
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeRadiotherapy plays a pivotal role in breast cancer treatment. Incidental irradiation of the heart can cause cardiac toxicity. We conducted a dosimetric comparison between Hybrid VMAT (H-VMAT) and 3D Conformal Radiotherapy (3DCRT) in both Free Breathing (FB) and Deep inspiration breath hold (DIBH) techniques for left-sided breast cancer patients. MATERIALS AND
methodsThirty-seven patients underwent CT scans in both FB and DIBH positions. Heart substructures were delineated following established guidelines. Subsequently, 3DCRT and H-VMAT plans were generated for each patient in both breath techniques. The dosimetric parameters of heart and its cavities were analysed: D
resultsThe analysis revealed statistically significant differences for the heart, and its cavities. The 3DCRT plans generated in DIBH offered a statistically significant lower dose for the heart and its substructures compared to the other techniques. When comparing PTV dosimetry, the H-VMAT plans showed an increase D98%(%) and a decrease D2%(%) relative to the 3DCRT plans, for both breathing techniques employed.
conclusionOur study demonstrates significant differences in the dosimetric outcomes for the heart substructures among the four evaluated techniques, with 3DCRT in DIBH yielding the lowest parameters for most substructures. Although H-VMAT provided superior target coverage, it resulted in greater low doses incidental exposure of the heart substructures. Notably, 3DCRT plans in the DIBH setting exhibited lower doses compared to H-VMAT in FB, supporting its preferential use for minimising cardiac exposure.
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