Evidence map›Paper›PMID 40413670›Full record

ArticleJournal of neurology2025

Association between vascular risk factors burden and neurodegenerative diseases: results from ONDRI.

Manuel Montero-Odasso, Frederico Pieruccini-Faria, Sandra E Black, Malcolm A Binns, Morris Freedman, David A Grimes, Robert A Hegele, Seyyed Hassan Haddad, Anthony E Lang, Mario Masellis and 20 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Manuel Montero-Odasso *Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, Western University, London, ON, Canada. mmontero@uwo.ca.ORCID http://orcid.org/0000-0002-5796-2361
Frederico Pieruccini-Faria *Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, Western University, London, ON, Canada.
Sandra E BlackDepartment of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Malcolm A BinnsRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Morris FreedmanRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
David A GrimesDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Robert A HegeleRobarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Seyyed Hassan HaddadRobarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Anthony E LangMorton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, The Department of Medicine, University of Toronto, Toronto, ON, Canada.
Mario MasellisDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Jennifer MandziaDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Derek BeatonData Science & Advanced Analytics, Unity Health Toronto, University of Toronto, Toronto, ON, Canada.
Joel RamirezHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Angela C RobertsDepartment of Computer Science, University of Western Ontario, London, ON, Canada.
William McIlroyDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Stephen H PasternakLawson Health Research Institute, London, ON, Canada.
Lorne ZinmanSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Agessandro AbrahaoSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Rick H SwartzHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Sean SymonsDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Brian TanRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Carmela TartagliaDivision of Neurology, Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Surim SonDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Ryota SakuraiResearch Team for Social Participation and Community Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Allison DilliottDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Quebec, Canada.
Benjamin F CornishDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Areej HezamLawson Health Research Institute, London, ON, Canada.
Michael J StrongRobarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
ONDRI Investigators
Robert BarthaDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular risk factors are common in older adults and contribute to brain damage, can manifest as increased white matter hyperintensities (WMH), and associated with future risk of stroke and dementia. However, their prevalence, effect across different neurodegenerative diseases, and association with WMH remains underexplored.

objectiveTo investigate the association between vascular risk burden, and brain white matter integrity, across five neurodegenerative conditions.

methodsCross-sectional study including 520 participants from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) cohorts: 126 with amnestic Mild Cognitive Impairment/Alzheimer's Disease (MCI/AD), 53 with Frontotemporal Dementia (FTD), 161 with Cerebrovascular Disease (CVD), 140 with Parkinson's Disease (PD), and 40 with Amyotrophic Lateral Sclerosis (ALS), along with 41 cognitively healthy controls. A vascular risk index (VRI, range 0-5) assessed hypertension, diabetes, dyslipidemia, obesity (BMI ≥ 30), and smoking history. Macro (WMH volume) and micro (Diffusion tensor imaging) white matter integrity were evaluated using 3-Tesla MRI. Associations were analyzed using multinomial logistic regression and ANCOVA, adjusting for age, sex, education, and APOE ε4 allele status.

resultsVascular risk factors, particularly hypertension and hypercholesterolemia, were more prevalent in the disease cohorts than controls. A higher VRI was significantly associated with MCI/AD (1.5-fold, p = 0.05), FTD (1.7-fold, p =0 .02), and CVD (2.6-fold, p < 0.005) cohorts. High VRI was associated with reduced macro and microstructural white matter integrity in the pooled sample (macro: p = 0.005; micro: p = 0.003), and separately in CVD (macro: p = 0.04; micro: p = 0.002). APOE ε4 status only mildly attenuated these associations.

conclusionVascular risk burden is prevalent in neurocognitive syndromes including MCI/AD, FTD and CVD, and impacts white matter integrity. Future studies are needed to explore if vascular risk management may mitigate the consequences of neurodegeneration in these clinical groups.

Indexed as

Cerebrovascular DisordersNeurodegenerative DiseasesWhite MatterAgedAged, 80 and overCognitive DysfunctionCohort StudiesCross-Sectional StudiesDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOntarioRisk FactorsAgedCardiovascular factorsCohort studyDementiaNeurodegenerationVascular riskWhite matter hyperintensity

Identifiers

PMID40413670

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.