Evidence map›Paper›PMID 40413531›Full record

ArticleActa neuropathologica communications2025

Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay.

Remarh Bsoul, Oskar H McWilliam, Gunhild Waldemar, Steen G Hasselbalch, Anja H Simonsen, Christian von Buchwald, Magne Bech, Clara H Pinborg, Christian K Pedersen, Sara O Baungaard and 8 more

Abstract read
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Remarh Bsoul *Danish Reference Center for Prion Diseases, Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
Oskar H McWilliam *Danish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Gunhild WaldemarDanish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Steen G HasselbalchDanish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Anja H SimonsenDanish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Christian von BuchwaldDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Magne BechDept. of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Clara H PinborgDept. of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Christian K PedersenDept. of Otolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Sara O BaungaardDanish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
José LombardíaDanish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Patrick EjlerskovDanish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Matilde BongianniDepartment of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Policlinico G. B. Rossi, Verona, Italy.
Erika BronzatoDepartment of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Policlinico G. B. Rossi, Verona, Italy.
Gianluigi ZanussoDepartment of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Policlinico G. B. Rossi, Verona, Italy.
Kristian S FrederiksenDanish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Eva L LundDanish Reference Center for Prion Diseases, Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
Aušrinė AreškevičiūtėDanish Reference Center for Prion Diseases, Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark. ausrine.areskeviciute@regionh.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, early diagnosis of dementia with Lewy bodies (DLB) is based on clinical criteria, which is challenging due to overlapping symptoms with other neurodegenerative diseases. Seeding amplification assays, detecting minute amounts of disease causing α-synuclein (αSyn

Indexed as

alpha-SynucleinLewy Body DiseaseOlfactory MucosaSkinAgedAged, 80 and overFemaleHumansMaleMiddle AgedSalivaSensitivity and Specificityalpha-SynucleinAmplification assayCerebrospinal fluidLewy bodyNeurodegenerativeOlfactory mucosaReal-time quaking-induced conversionRT-QuICSkinUrine

Identifiers

PMID40413531
PMCPMC12102825

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.