Evidence map›Paper›PMID 40413521›Full record

ArticleBMC public health2025

Global and regional disease burden of HIV/AIDS from 1990 to 2021 and projections to 2030.

Youwang Lu, Huiqin Li, Rongjing Dong, Mi Zhang, Xingqi Dong, Cuixian Yang, Xicheng Wang, Junchuan Ye

Abstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Youwang Lu *Yunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, China.
Huiqin Li *Yunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, China.
Rongjing Dong *Hubei Provincial Key Laboratory of Occurrence and Intervention of Kidney Diseases, Medical College, Hubei Polytechnic University, Huangshi, China.
Mi ZhangYunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, China.
Xingqi DongYunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, China.
Cuixian YangYunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, China.
Xicheng WangYunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, China. wxch62597@foxmail.com.
Junchuan YeYunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, China. junchuanye@163.com.

Funding

National Natural Science Foundation of China 82203934the 13th Five Year Plan of the Ministry of Science and Technology of China for the prevention and treatment of major infectious diseases such as AIDS and viral hepatitis 2017ZX10202101-002, 2017ZX10202101-003the Talent Introduction Project of Hubei Polytechnic University 21xjz33Rthe Talent Introduction Project of Hubei Polytechnic University 21xjz34RYunnan Clinical Research Center for Infectious Disease (AIDS) 202405AJ310002
6 · The paper itself

Abstract

backgroundFew studies have focused on the descriptive epidemiology and trends of HIV/AIDS since the publication of the Global Burden of Disease (GBD) study in 2021. Therefore, this study aims to analyze the trends and patterns of the HIV/AIDS burden at the global, regional, and national levels by sex, age and social development index (SDI). We also explored risk factors and predicted the GBD of HIV/AIDS until 2030.

methodsData on the etiology of HIV/AIDS from 1990 to 2021 were collected from the 2021 GBD database. Estimated annual percent changes (EAPCs) were calculated to assess temporal trends in the age-standardized incidence rate (ASIR), age-standardized disability-adjusted life-year rate (ASDR) and age-standardized mortality rate (ASMR) of HIV/AIDS patients. Measures categorized by sex, region, age and SDI quintiles. In addition, an age‒period‒cohort model was established to forecast future trends of the HIV/AIDS burden to 2030.

resultsGlobally, the incidence of HIV/AIDS reached 1.65 million (95% uncertainty interval 1.48 to 1.82) in 2021. From 1990 to 2021, the global ASIR of HIV/AIDS showed a downward trend, with an EAPC of 0.14% (0.12-0.16%). The ASIR, ASDR, and ASMR of HIV/AIDS were highest in the low-SDI region and lowest in the high-SDI region. Regionally, southern sub-Saharan Africa had the highest ASIR in 2021, whereas Oceania had the largest increase in the ASIR from 1990 to 2021. Burundi (EAPC 14.04%, 95% CI -13.63 to -14.44%), followed by Burkina Faso, exhibited the most significant decrease in the ASIR. Globally, the highest incidence rate was observed in the 25-29 years old group. Unsafe sex is the primary factor leading to the burden of HIV/AIDS. By 2030, the global ASIR, ASDR and ASMR of HIV/AIDS are expected to gradually decrease.

conclusionHIV/AIDS disease burden varies by region, sex, and age. The global burden of HIV/AIDS is substantial in low-income regions, especially in Sub-Saharan Africa. Our study offers valuable epidemiological evidence for future research on the prevention and treatment of HIV/AIDS.

Indexed as

Acquired Immunodeficiency SyndromeCost of IllnessGlobal Burden of DiseaseGlobal HealthHIV InfectionsAdolescentAdultAgedChildChild, PreschoolDisability-Adjusted Life YearsFemaleForecastingHumansIncidenceMaleDisability-adjusted life-yearsGlobal burden of diseaseHIV/AIDSIncidenceMortalityRisk factors

Identifiers

PMID40413521
PMCPMC12103032

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.