Evidence map›Paper›PMID 40413460›Full record

ArticleBMC oral health2025

The activation of CB2 enhances bone remodeling in periodontitis.

Yuan Zhao, Yixuan Zhang, Huijuan Liu, Xing Qiao, Dongna Li, Yahui Zhu, Zidan Wu, Wenqi Wang, Zhe Ma, Chunyan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan Zhao *Department of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology & Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050000, China.
Yixuan Zhang *Department of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology & Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050000, China.
Huijuan LiuThe Key Laboratory of Stomatology, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050017, China.
Xing QiaoDepartment of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology & Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050000, China.
Dongna LiDepartment of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology & Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050000, China.
Yahui ZhuDepartment of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology & Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050000, China.
Zidan WuHebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Wenqi WangHebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Zhe MaDepartment of Preventive Dentistry, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology & Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050017, China. mazhe@hebmu.edu.cn.
Chunyan LiuDepartment of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology & Hebei Technology Innovation Center of Oral Health, Hebei Medical University, East 383 Zhongshan Road, Shijiazhuang, Hebei Province, 050000, China. chunyanliu@hebmu.edu.cn.

Funding

Hebei Province Education Department's Graduate Innovation Fund Project for Universities XCXZZS202311S&T Program of Hebei 236Z7740G
6 · The paper itself

Abstract

objectivesThe cannabinoid receptor 2 (CB2) is implicated in bone metabolism and reconstruction of periodontal tissues. However, its role in bone formation during periodontitis remains to be elucidated. This study aims to explore the impact of CB2 on alveolar bone in periodontitis, as well as the associated signaling pathways.

methodsWild type (WT) and CB2 knockout (Cnr2

resultsThe absence of CB2 (Cnr2 knockout, Cnr2

conclusionsThe inhibition of CB2 facilitates osteoclast recruitment and exacerbates periodontitis. CB2 may promote the osteogenic differentiation of PDLSCs by activating ERK1/2 pathway.

Indexed as

Bone RemodelingPeriodontitisReceptor, Cannabinoid, CB2Alveolar Bone LossAnimalsCell DifferentiationCells, CulturedDisease Models, AnimalHumansLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutOsteoclastsOsteogenesisLipopolysaccharidesReceptor, Cannabinoid, CB2Cannabinoid receptor 2Osteogenic differentiationPeriodontal ligament stem cellsPeriodontitis

Identifiers

PMID40413460
PMCPMC12102886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.