Evidence map›Paper›PMID 40413455›Full record

ArticleJournal of health, population, and nutrition2025

Global, regional and national burdens of alcoholic cardiomyopathy among the working-age population, 1990-2021: a systematic analysis.

Zhongkai Wang, Changyong Wu, Bingqing Zhang, Huang Sun, Wenjie Liu, Yuan Yang, Ying Gu, Lifei Pu, Lihui Zheng, Suli Bao and 3 more

Abstract read
In one paragraph

Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhongkai Wang *Cardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Changyong Wu *Cardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Bingqing Zhang *Cardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Huang SunCardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Wenjie LiuCardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yuan YangDepartment of Clinical Pharmacy, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Ying GuDepartment of Ultrasound, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Lifei PuDepartment of Otolaryngology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Lihui ZhengCardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Suli BaoCardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yihua LuoCardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
Ruijie LiCardiovascular Clinical Medical Center, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China. liruijie@ydyy.cn.
Yunzhu PengDepartment of Cardiology, Second People's Hospital of Yunnan Province, China, Kunming, China. pengyunzhu0308@163.com.

Funding

Medical leading Talents Training Program of Yunnan Provincial Health Commission L-2019026the National Nature Science Foundation of China 82160439Yunnan Provincial Training Project of High-level Talents RLMY-20200001
6 · The paper itself

Abstract

objectivesAlcoholic cardiomyopathy (ACM) results from chronic alcohol misuse and primarily affects the working-age population (15-64 years). The global age-standardized rates (ASRs) of ACM disease burden declined slightly from 1990 to 2021, but the absolute cases increased, especially in high‒medium sociodemographic index (SDI) regions such as Eastern Europe. The aim of this study was to inform strategies to combat this preventable yet escalating health issue.

methodsWe calculated estimated annual percentage changes (EAPCs) to quantify the dynamics of prevalence, deaths, and disability-adjusted life years (DALYs) for ACM. Decomposition analysis quantifies the contributor of disease burden in ACM. Additionally, we employed a health inequality analysis with two core indicators, the slope index (SI) and the concentration index (CIN), to assess national differences in the burden of ACM in relation to the SDI. Frontier analysis was used to identify preventable burdens with respect to optimized alcohol policies, particularly in high-middle SDI countries. Finally, we applied a Bayesian age‒cohort (BAPC) model to project the ACM burden to 2035.

resultsThis study revealed that the ASRs of prevalence, deaths, and DALYs decreased slightly from 1990 to 2021, whereas absolute cases of ACM continued to increase globally. Global income-based health disparities in ACM have intensified over the past 32 years, with high SDI populations disproportionately favoured. Population growth was the main driver of the increased ACM burden. The global burden of ACM is expected to increase in the future according to the BAPC model.

conclusionsThe global burden of ACM continues to rise, primarily due to population ageing and insufficient prevention policies. This burden disproportionately impacts working-age populations, who face heightened vulnerability due to alcohol accessibility, premature mortality, and reduced workforce productivity. Moreover, economic growth paradoxically coincides with increased alcohol-related harm in regions with high-middle socioeconomic development-the alcohol control paradox. Projections highlight an urgent need for tailored alcohol control strategies, including stricter regulation and early cardiac screening in high-risk groups, to mitigate workforce productivity loss and align public health priorities with sustainable development goals.

Indexed as

Cardiomyopathy, AlcoholicCost of IllnessGlobal HealthAdolescentAdultBayes TheoremDisability-Adjusted Life YearsFemaleGlobal Burden of DiseaseHealth Status DisparitiesHumansMaleMiddle AgedPrevalenceQuality-Adjusted Life YearsSocioeconomic FactorsAlcoholic cardiomyopathyGlobal burden of diseaseHealth inequalitySociodemographic indexTemporal trends

Identifiers

PMID40413455
PMCPMC12103052

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.