Evidence map›Paper›PMID 40413439›Full record

SynthesisVirology journal2025

Sensory neuropathy and associated factors among patients living with human immuno-deficiency virus in Africa: a systematic review and meta-analysis.

Worku Chekol Tassew, Ashebir Mamay Gebiru, Mihret Getnet, Berihun Agegn Mengistie, Desalegn Anmut Bitew, Amare Belete Getahun, Desale Bihonegn Asmamaw, Mikias Mered Tilahun, Mihret Melese, Nebebe Demis Baykemagn and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Worku Chekol TassewDepartment of Medical Nursing, Teda Health Science College, Gondar, Ethiopia. workukid16@gmail.com.
Ashebir Mamay GebiruDepartments of Health Informatics, Teda Health Science College, Gondar, Ethiopia.
Mihret GetnetDepartment of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Berihun Agegn MengistieDepartment of General Midwifery, School of Midwifery, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Desalegn Anmut BitewDepartment of Reproductive Health, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Amare Belete GetahunDepartment of Anesthesia, School of Medicine,College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Desale Bihonegn AsmamawDepartment of Optometry, College of Medicine and Health Science, School of Medicine, University of Gondar, Comprehensive Specialized Hospital, Gondar, Ethiopia.
Mikias Mered TilahunDepartment of Occupational Health and Safety, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Mihret MeleseDepartment of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Nebebe Demis BaykemagnDepartments of Health Informatics, Teda Health Science College, Gondar, Ethiopia.
Yimer MamayeDepartment of Human Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Yosef Belay BizunehDepartment of Anesthesia, School of Medicine,College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Habtu Kifle NegashDepartment of Human Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite high prevalence of sensory neuropathy among individuals living with HIV, there is no comprehensive information regarding variables that determine sensory neuropathy onset among the patients who attended health care facilities. In conditions where there is a high number of patients with sensory neuropathy, clinicians confront challenges in managing the problem, and increase the burden of health care expenditures. This study aimed to determine the prevalence of peripheral neuropathy and associated factors among people living with HIV in Africa.

methodsTo ensure the transparency, accuracy, and thoroughness of this systematic review and meta-analysis, we adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Systematic electronic searches were conducted across several databases, including African Journal Online, Google Scholar, PubMed, Scopus, and the Wiley Online Library. Articles found during the searching were imported into EndNote software version X7, where duplicates were removed. The extracted data were then imported to Microsoft Excel and analyzed using STATA version 11 for analysis. The Q statistic and I

resultsThe initial search identified 1,821 articles, which were organized using citation management software. The current meta-analysis found that 36.46% (95% CI: 26.48-46.44, I

conclusionThis study found that peripheral sensory neuropathy is highly prevalent among HIV-infected individuals in Africa. Advanced age, elevated viral load, and low CD4 count were identified as independent predictors of HIV-related peripheral neuropathy. It is recommended that simple, established neurological screening methods be regularly used to identify early signs of HIV-SN or individuals at risk, across all patients.

Indexed as

HIV InfectionsPeripheral Nervous System DiseasesAdultAfricaFemaleHumansMalePrevalenceRisk FactorsAfricaHIV/AIDSMeta-analysisSensory neuropathySystematic review

Identifiers

PMID40413439
PMCPMC12102978

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.