ArticleBMC anesthesiology2025
Association of exhaled breath volatile organic compounds with surgical traumatic stress.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
purposeThis study explored the association of surgical traumatic stress with volatile organic compounds (VOCs) in breath.
methodsExhaled breath and blood samples were collected from 105 patients under general anesthesia at three time points: prior to incision (Pre-op), 2 h after incision (Intra-op), and prior to extubation (End-op). Differential mass spectral features between these time points were screened. Traumatic stress-related biomarker detection and mixed-effects model analysis were performed to define correlations and significance between parameters. Subgroup analysis was conducted to test the ability of mass spectral features to distinguish different surgical routes (open vs. laparoscopic).
resultsThe abundances of mass spectral features changed significantly between these time points. All stress-related biomarker increased dramatically in the Intra-op group and decreased significantly after operation. Mixed-effects model analysis revealed that several features were significantly correlated with stress biomarkers. Most importantly, subgroup analysis revealed that different surgical routes failed to be distinguished by mass spectral features.
conclusionSurgical traumatic stress may change the exhaled breath mass spectral features in perioperative patients, providing preliminary evidence for mass spectral features use in future monitoring of this stress response.
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