Evidence map›Paper›PMID 40413392›Full record

SynthesisBMC infectious diseases2025

Prevalence of hepatitis B virus infection and its associated factors in Ethiopia: a recent systematic review and meta-analysis.

Senait Tadesse, Abaineh Munshea, Baye Gelaw, Norbert Peshu, Endalamaw Tesfa, Feleke Mekonnen, Mulugeta Mihrete Tefera, Getachew Kahsu, Demeke Endalamaw, Anna Kramvis and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Senait TadesseHealth Biotechnology Division, Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia. tadesenait@gmail.com.
Abaineh MunsheaHealth Biotechnology Division, Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia.
Baye GelawMedical Microbiology Department, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Norbert PeshuCenter for Geographical Medicine Research, Kenya Medical Research Institute, Coast Kilifi, Kenya.
Endalamaw TesfaDepartments of Biochemistry, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Feleke MekonnenHealth Biotechnology Division, Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia.
Mulugeta Mihrete TeferaBahir Dar Health Science College, Bahir Dar, Ethiopia.
Getachew KahsuCollege of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Demeke EndalamawHealth Biotechnology Division, Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia.
Anna KramvisDepartment of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Meseret AdugnaDepartment of Internal Medicine, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Steve WandigaKenya Medical Research Institute, Nairobi, Kenya.

Funding

National Institute for Health Research (NIHR) (PSIA2020-3073) using United Kingdom (UK) Aid from the UK Government to support global health research, as part of the EDCTP2 Programme supported by the European Union. PSIA2020AGDG-3318
6 · The paper itself

Abstract

backgroundHepatitis B virus (HBV) is one of the most common causes of chronic liver disease and is a growing concern in low-income countries, including Ethiopia. Different studies have been conducted on the prevalence of HBV infection among Ethiopian regions and population segments. Therefore, this systematic review was commenced to summarize these findings, deliver representative pooled data on the prevalence of HBV infection among Ethiopian administrative regions and population segments, and identify possible factors associated with HBV infection.

methodsElectronic databases such as PubMed, African Journals Online, and Google Scholar were searched for published articles from July 9, 2019, to February 30, 2024. The data were exported to STATA version 15.1 for meta-analyses. The heterogeneity between the results of the primary studies was accessed using Cochran's Q chi-square test and quantified with I

resultsThe overall pooled prevalence of HBV infection was 6.9% (95% CI: 6.1, 7.7). Among the subgroup analyses, the highest pooled prevalence of HBV infection was obtained from Harar city 9.6% (95% CI: 5.6, 13.5), followed by South Nations and Nationalities People Regions (SNNPR) 8.5% (95% CI: 7.4, 9.7). On the other hand, the pooled prevalence of HBV infection among waste handlers was high 12.6% (95% CI: 2.4, 27.6) followed by female commercial sex workers (FCSW) 10.9% (95% CI: 7.7, 15.2) and human immune deficiency virus (HIV) positive individuals 9.9% (95% CI: 7.2, 12.8). HBV infection was significantly linked to the following factors: those with multiple sexual partners, a family history of chronic liver disease, exposure to bodily fluids, HIV seropositivity, and sharp needle injury had Adjusted Odd Ratio (AOR):3.9 (95% CI: 2.62, 5.76), (AOR: 6.9 (95% CI:3.46, 10.53), (AOR:3.1 (95% CI: 2.01, 3.05), (AOR:7.7 (95% CI: 2.99, 19.93), (AOR:2.1 (95% CI: 1.58, 2.66) times a greater chance of infection, respectively.

conclusionsThe high pooled prevalence of HBV infection in Ethiopia indicates that the burden of HBV infection continues to be a public health concern. The Ethiopian Ministry of Health should develop a strategic plan for prevention and control of HBV infection transmission including awareness creation, scale-up screening programs, diagnosis, treatment, and care services to reduce the burden of HBV infection and eliminate it as a public health threat.

Indexed as

Hepatitis BEthiopiaFemaleHepatitis B virusHIV InfectionsHumansMalePrevalenceRisk FactorsEthiopiaHepatitis B virusPrevalenceRisk factors

Identifiers

PMID40413392
PMCPMC12103763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.