Evidence map›Paper›PMID 40413353›Full record

ReviewMikrochimica acta2025

Applications of microfluidic chip technology in microvascular thrombosis research.

Zhichang Du, Xiaolong Hu, Yurui Lin, Ling Chen, Yan Huang, Jianyu Fan, Shaohui Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhichang DuCollege of Marine Equipment and Mechanical Engineering, Jimei University, Xiamen, 361021, China. 202061000118@jmu.edu.cn.
Xiaolong HuCollege of Marine Equipment and Mechanical Engineering, Jimei University, Xiamen, 361021, China.
Yurui LinCollege of Marine Equipment and Mechanical Engineering, Jimei University, Xiamen, 361021, China.
Ling ChenCollege of Marine Equipment and Mechanical Engineering, Jimei University, Xiamen, 361021, China.
Yan HuangCollege of Marine Equipment and Mechanical Engineering, Jimei University, Xiamen, 361021, China.
Jianyu FanCollege of Marine Equipment and Mechanical Engineering, Jimei University, Xiamen, 361021, China.
Shaohui YangCollege of Marine Equipment and Mechanical Engineering, Jimei University, Xiamen, 361021, China. shaohuiyang@jmu.edu.cn.

Funding

National Natural Science Foundation of China Grant No.32201185Natural Science Foundation of Fujian Province Grant No.2021H6008
6 · The paper itself

Abstract

The formation and progression of microvascular thrombosis are critical mechanisms underlying many vascular-related diseases. Therefore, replicating the microvascular blood flow environment in vitro and investigating the mechanisms of microvascular thrombosis formation are highly significant. In recent years, microfluidic chip technology has been extensively applied in in vitro research for its capability to systematically and comprehensively replicate the complex processes of microvascular thrombosis in laboratory settings. This review systematically examines the development and applications of microfluidic chip technology in microvascular thrombosis research. It begins with a brief summary of the technical features of microfluidic chip technology, followed by a detailed discussion of its applications in constructing in vitro microvascular models, investigating thrombosis mechanisms, and evaluating antithrombotic drug efficacy. Finally, the review summarizes the current research progress and discusses potential directions for future development. This review also systematically explains the breakthrough contribution of microfluidic chips from the perspective of engineering bionics and provides new insights for the pathological research and clinical management of microvascular thrombosis: constructing a high-precision physiological simulation system through bionic topology design and dynamic fluid regulation to achieve high-precision reconstruction of vascular dynamic microenvironment; based on the systems-level dynamics analysis, the dynamic evolution law of multi-factor synergy in the process of thrombosis is revealed; construct a drug-response evaluation system and establish a transformation bridge from micro-mechanism to clinical intervention. In summary, this review is expected to accelerate the development of targeted therapies and diagnostic tools for microvascular thrombosis.

Indexed as

Lab-On-A-Chip DevicesMicrofluidic Analytical TechniquesMicrovesselsThrombosisAnimalsHumansIn vitro microvascular modelsMicrofluidic chip technologyMicrovascular thrombosisPharmacological analysisPlatelets

Identifiers

PMID40413353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.