Evidence map›Paper›PMID 40413239›Full record

ArticleScientific reports2025

ATR-FTIR spectroscopic markers indicating drug resistance in selected Candida strains.

Agnieszka Dróżdż, Dominika Kubera, Alina Olender, Wojciech Dabrowski, Magdalena Szukala, Sylwia Wosko, Joanna Chwiej, Marzena Rugiel, Kamil Kawoń, Mariusz Gagoś

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Cell surface (Amsterdam, Netherlands) · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Agnieszka DróżdżFaculty of Physics and Applied Computer Science, AGH University of Krakow, al. A. Mickiewicza 30, 30-059, Krakow, Poland. agnieszka.drozdz@fis.agh.edu.pl.
Dominika KuberaDepartment of Cell Biology, Maria Curie-Sklodowska University, Akademicka 19, 20-033, Lublin, Poland.
Alina OlenderDepartment of Medical Microbiology, Medical University of Lublin, Chodźki 1 Street, 20-093, Lublin, Poland.
Wojciech DabrowskiFirst Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Jaczewskiego street 8, 20-090, Lublin, Poland.
Magdalena SzukalaFirst Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Jaczewskiego street 8, 20-090, Lublin, Poland.
Sylwia WoskoLaboratory of Preclinical Testing, Department of Applied and Social Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 20-293, Lublin, Poland.
Joanna ChwiejFaculty of Physics and Applied Computer Science, AGH University of Krakow, al. A. Mickiewicza 30, 30-059, Krakow, Poland.
Marzena RugielFaculty of Physics and Applied Computer Science, AGH University of Krakow, al. A. Mickiewicza 30, 30-059, Krakow, Poland.
Kamil KawońFaculty of Physics and Applied Computer Science, AGH University of Krakow, al. A. Mickiewicza 30, 30-059, Krakow, Poland.
Mariusz GagośDepartment of Cell Biology, Maria Curie-Sklodowska University, Akademicka 19, 20-033, Lublin, Poland. mariusz.gagos@mail.umcs.pl.

Funding

Polish National Science Centre 2019/35/B/NZ7/02756
6 · The paper itself

Abstract

The rising incidence of fungal infections and the increasing prevalence of antifungal resistance highlight the need for rapid and reliable diagnostic methods. This study investigates the potential of ATR-FTIR spectroscopy to identify spectroscopic markers of drug resistance in selected Candida strains. In this pilot study, ATR-FTIR spectroscopy was employed to analyse the biochemical composition of Candida albicans, Candida glabrata and Candida dubliniensis isolates. The minimum inhibitory concentrations (MIC) of antifungals were determined using antifungals concentration gradient strips, and the spectral data were processed to identify differences between resistant and sensitive isolates. Based on the results for Candida albicans, Candida glabrata and Candida dubliniensis, specific ATR-FITR spectroscopic markers of drug resistance were identified, which highlighted the necessity for these markers to be antifungal-specific. Despite the limitations of the study, the findings underscore the potential of ATR-FTIR spectroscopy in identifying spectroscopic markers of antifungal resistance. These preliminary results provide a foundation for further research, which could lead to the development of rapid diagnostic tools for detecting drug-resistant Candida strains, thereby improving the management and treatment of fungal infections.

Indexed as

Antifungal AgentsCandidaDrug Resistance, FungalBiomarkersCandidiasisHumansMicrobial Sensitivity TestsPilot ProjectsSpectroscopy, Fourier Transform InfraredAntifungal AgentsBiomarkersAntifungal resistanceATR-FTIR spectroscopyCandidaDrug resistanceMultidrug resistanceSpectroscopic markers

Identifiers

PMID40413239
PMCPMC12103571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.