Evidence map›Paper›PMID 40413176›Full record

ArticleNature communications2025

CXCR4

Eunmi Lee, Jason J Hong, Gabriel Samcam Vargas, Natalie Sauerwald, Yong Wei, Xiang Hang, Chandra L Theesfeld, Jean Arly A Volmar, Jennifer M Miller, Wei Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eunmi LeeDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Jason J HongDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.ORCID http://orcid.org/0000-0002-4631-131X
Gabriel Samcam VargasDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.ORCID http://orcid.org/0009-0005-5353-1387
Natalie SauerwaldCenter for Computational Biology, Flatiron Institute, New York, NY, 10010, USA.
Yong WeiDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.ORCID http://orcid.org/0000-0002-1034-649X
Xiang HangDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Chandra L TheesfeldLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, USA.ORCID http://orcid.org/0000-0002-8379-6600
Jean Arly A VolmarLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, USA.
Jennifer M MillerLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, USA.
Wei WangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, USA.ORCID http://orcid.org/0000-0002-6558-4858
Sha WangDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Gary LaevskyDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Christina J DeCosteDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Yibin KangDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA. ykang@princeton.edu.ORCID http://orcid.org/0000-0002-1626-6730

Funding

Metadherin in Metastasis and Chemoresistance of Breast CancerR01CA134519 · NCI · PRINCETON UNIVERSITY · PI KANG, YIBIN · 2008 to 2012
$1.6M
U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA134519
6 · The paper itself

Abstract

Tumor-initiating cells (TICs) share features and regulatory pathways with normal stem cells, yet how the stem cell niche contributes to tumorigenesis remains unclear. Here, we identify CXCR4

Indexed as

Breast NeoplasmsCarcinogenesisMacrophagesMammary Glands, AnimalNeoplastic Stem CellsReceptors, CXCR4Stem Cell NicheAnimalsbeta CateninChemokine CXCL12FemaleHumansMammary Glands, HumanMiceProto-Oncogene Proteins c-aktT-Lymphocytes, Regulatorybeta CateninChemokine CXCL12CXCL12 protein, humanCXCR4 protein, humanCXCR4 protein, mouseProto-Oncogene Proteins c-aktReceptors, CXCR4

Identifiers

PMID40413176
PMCPMC12103607

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.