Evidence map›Paper›PMID 40413169›Full record

ArticleNature communications2025

Enabling pan-repository reanalysis for big data science of public metabolomics data.

Yasin El Abiead, Michael Strobel, Thomas Payne, Eoin Fahy, Claire O'Donovan, Shankar Subramamiam, Juan Antonio Vizcaíno, Ozgur Yurekten, Victoria Deleray, Simone Zuffa and 12 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Article
  3. Network-based integration of metabolomics data from large-scale repositories.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Alkamines reveal a hidden layer of steroid and drug metabolism.bioRxiv : the preprint server for biology · 2026
    Article
  10. Review
  11. Article
  12. Mapping the mammalian dark metabolome bybioRxiv : the preprint server for biology · 2026
    Article
  13. Pan-Metabolomics Repository Mapping of the Carnitine Landscape.bioRxiv : the preprint server for biology · 2026
    Article
  14. Review
  15. Navigating the conjugated metabolome.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yasin El AbieadSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4392-7706
Michael StrobelDepartment of Computer Science and Engineering, University of California Riverside, Riverside, CA, USA.
Thomas PayneEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Eoin FahyDepartment of Bioengineering, and San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0505, USA.ORCID http://orcid.org/0000-0003-3196-522X
Claire O'DonovanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Shankar SubramamiamDepartment of Bioengineering, and San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0505, USA.
Juan Antonio VizcaínoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.ORCID http://orcid.org/0000-0002-3905-4335
Ozgur YurektenEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Victoria DeleraySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Simone ZuffaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7237-3402
Shipei XingSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Helena Mannochio-RussoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Ipsita MohantySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0894-4770
Haoqi Nina ZhaoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3908-630X
Andres M Caraballo-RodriguezSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Paulo Wender P GomesSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Nicole E AvalonCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0003-3588-892X
Trent R NorthenEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Lab, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0001-5903-1870
Benjamin P BowenEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Lab, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0003-1368-3958
Katherine B LouieThe DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-6787-7558
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3003-1030
Mingxun WangDepartment of Computer Science and Engineering, University of California Riverside, Riverside, CA, USA. mingxun.wang@cs.ucr.edu.ORCID http://orcid.org/0000-0001-7647-6097

Funding

Metabolomics Workbench - National Metabolomics Data RepositoryU24DK141185 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shankar Subramaniam · 2024 to 2026
$4.2M
NIDDK NIH HHS U24 DK141185
6 · The paper itself

Abstract

Public untargeted metabolomics data is a growing resource for metabolite and phenotype discovery; however, accessing and utilizing these data across repositories pose significant challenges. Therefore, here we develop pan-repository universal identifiers and harmonized cross-repository metadata. This ecosystem facilitates discovery by integrating diverse data sources from public repositories including MetaboLights, Metabolomics Workbench, and GNPS/MassIVE. Our approach simplified data handling and unlocks previously inaccessible reanalysis workflows, fostering unmatched research opportunities.

Indexed as

Big DataData ScienceMetabolomicsDatabases, FactualHumansMetadata

Identifiers

PMID40413169
PMCPMC12103507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.