Observational studyBMJ open2025
Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
objectiveThe current study aimed to compare the relationship between polycyclic aromatic hydrocarbons (PAHs) exposure and thyroid hormone (TH) sensitivity markers in individuals with normal thyroid function in the USA population during 2007-2008 and 2009-2012.
designObservational cross-sectional study.
settingUS population data from 2007 to 2008 and 2009 to 2012.
main outcome measuresAssociations between PAH exposure and TH sensitivity were examined, stratified by sex and age, along with dose-response relationships between PAH metabolites and TH sensitivity indices.
resultsIn women, after adjusting for confounding variables, 1-hydroxynaphthalene was positively associated with thyroid feedback quantile index of FT4 (TFQI
conclusionsIn the US population with normal thyroid function, PAH exposure may interfere with TH sensitivity, with effects varying by population characteristics.
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