Evidence map›Paper›PMID 40412797›Full record

ArticleJournal of molecular and cellular cardiology2025

The role of the troponin T interactions with actin in regulation of cardiac thin filament revealed by the troponin T pathogenic variant Ile79Asn.

Cristina M Risi, Maicon Landim-Vieira, Betty Belknap, P Bryant Chase, Jose R Pinto, Vitold E Galkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Thin filament interaction and CaJournal of molecular and cellular cardiology · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cristina M RisiDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA 23507, USA.
Maicon Landim-VieiraDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
Betty BelknapDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA 23507, USA.
P Bryant ChaseDepartment of Biological Science, Florida State University, Tallahassee, FL, USA.
Jose R PintoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
Vitold E GalkinDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA 23507, USA. Electronic address: galkinve@evms.edu.

Funding

REGULATION OF THE ACTIN FILAMENT POINTED END DYNAMICS IN HEALTH AND DISEASER01GM120137 · NIGMS · WASHINGTON STATE UNIVERSITY · PI GALKIN, VITOLD, GREGORIO, CAROL C · 2017 to 2024
$4.0M
The mechanisms of cardiac thin filament regulation in health and disease.R01HL160966 · NHLBI · OLD DOMINION UNIVERSITY · PI CHASE, P. BRYANT, GALKIN, VITOLD · 2022 to 2025
$2.3M
NHLBI NIH HHS R01 HL160966NIGMS NIH HHS R01 GM120137
6 · The paper itself

Abstract

Cardiac muscle contraction/relaxation cycle depends on the rising and falling Ca

Indexed as

Actin CytoskeletonActinsMyocardiumTroponin TAnimalsCalciumCryoelectron MicroscopyHumansMiceProtein BindingTropomyosinActinsCalciumTropomyosinTroponin TCardiomyopathyCryo-EMMuscle regulationThin filamentTroponin

Identifiers

PMID40412797
PMCPMC12172634

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.