ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025
Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review.Neuroscience applied · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundExtensive research has shown aberrant reward and punishment processing in people with depression. Genetic risks contribute to depression, but whether or how these risks of depression may affect behavioral and neural responses to reward and punishment remains unclear.
methodsWe curated the data of 879 young adults performing a gambling task during brain imaging from the Human Connectome Project. Depression severity was assessed with the Achenbach Adult Self Report. Polygenic risk scores (PRSs) for depression were computed for all participants. With published routines and at a corrected threshold, we evaluated how brain responses to reward and punishment were associated with depression scores and PRSs in a linear regression in all, male, and female participants, with age, sex (for all), race, and drinking severity as covariates.
resultsThe results showed broad frontal, parietal, and occipital cortical activation in negative correlation with PRSs during both reward and punishment processing. Notably, posterior cingulate cortical activation was specifically associated with PRS-related punishment processing. In addition, men and women displayed both shared and distinct neural responses to PRS-related reward and punishment processing.
conclusionsThese findings highlight the influence of genetic risks for depression on neural responses to reward and punishment and provide insights into genetically informed markers of depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.