Evidence map›Paper›PMID 40412614›Full record

Trial reportClinical nutrition ESPEN2025

Neuroprotective nutrients in pregnancy and infant brain function.

D N Christifano, K Liao, N B Mathis, S E Carlson, J Colombo, L Chollet-Hinton, K M Gustafson

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition ESPEN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

D N ChristifanoDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS 66103, USA. Electronic address: dchristifano@kumc.edu.
K LiaoDepartment of Neurology and Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66103, USA.
N B MathisDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS 66103, USA.
S E CarlsonDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS 66103, USA.
J ColomboDepartment of Psychology and Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, KS 66044, USA.
L Chollet-HintonDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS 66103, USA.
K M GustafsonDepartment of Neurology and Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66103, USA.

Funding

DHA Supplementation and Pregnancy OutcomeR01HD047315 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CARLSON, SUSAN E, COLOMBO, JOHN A. · 2006 to 2016
$4.9M
Prenatal DHA & Neurofunctional DevelopmentR01HD086001 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUSTAFSON, KATHLEEN M · 2016 to 2020
$3.1M
Psychometrics and Predictive Validity of Infant LearningR01HD109221 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI JOHN A. COLOMBO, Kimberly S Cuevas · 2023 to 2026
$2.6M
NICHD NIH HHS R01 HD047315NICHD NIH HHS R01 HD086001NICHD NIH HHS R01 HD109221
6 · The paper itself

Abstract

Neuroprotective nutrients including omega 3 fatty acid docosahexaenoic acid (DHA), choline, and carotenoids play an important role in infant brain structure and function; however, the effects of maternal nutrition on the infant brain are understudied. We leveraged data from our large randomized clinical trial among pregnant women to determine whether maternal nutrients including DHA, choline, lutein/zeaxanthin (L/Z) and egg intake (a food source of these nutrients) were related to infant brain function. Data from n = 241 maternal and infant dyads were included in this secondary analysis. Food frequency questionnaires (Diet History Questionnaire II) at 32 weeks' gestation were used to assess choline and carotenoid intake and a brief survey on egg consumption (# eggs consumed per week) was used to assess egg intake. Maternal red blood cell DHA status was measured at 32 weeks' gestation. Infant brain function was measured using high density electroencephalogram (EEG) to auditory (1 month of age) and visual (6 months of age) event-related potentials (ERP). At 1 month of age, maternal DHA status was associated with greater delta-band spectral power to the novel tone during the ERP. Choline, choline∗L/Z, L/Z∗DHA, and choline∗L/Z∗DHA were each related to power to the frequent tone during the ERP. At 6 months, choline, DHA status, and choline∗DHA were related to shorter latency to the novel visual stimulus. Choline∗L/Z and choline∗L/Z∗DHA were related to greater amplitude to the novel stimulus. Overall, maternal neuroprotective nutrients were related to several markers of infant brain function.

Indexed as

BrainMaternal Nutritional Physiological PhenomenaNeuroprotective AgentsNutrientsAdultCholineDietDocosahexaenoic AcidsEggsElectroencephalographyFemaleHumansInfantLuteinMalePregnancyCholineDocosahexaenoic AcidsLuteinNeuroprotective AgentsNutrientsZeaxanthinsCholineDocosahexaenoic acidInfant neurodevelopmentMaternal diet

Identifiers

PMID40412614
PMCPMC13182503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.